INMH 2014 poster (PDF)




File information


Title: Slide 1
Author: z9100677

This PDF 1.5 document has been generated by Acrobat PDFMaker 10.1 for PowerPoint / Adobe PDF Library 10.0, and has been sent on pdf-archive.com on 26/09/2014 at 08:16, from IP address 129.94.x.x. The current document download page has been viewed 363 times.
File size: 676.26 KB (1 page).
Privacy: public file




Document preview - INMH_2014_poster.pdf - Page 1/1





File preview


Spatial Orientation Performance
Differs Across Dementia Subtypes
Prince of Wales Clinical School

S. Tu1,2, S.Wong1,2, O. Piguet1,2, J. Hodges1,2 ,
M. Hornberger1,2
1Neuroscience

Research Australia
2ARC Centre of Excellence in Cognition and its Disorders

Background

Virtual Supermarket Task

 AD is the most common form of dementia, typically
present with marked memory deficits
 Patients with bvFTD also show memory impairment
resulting in diagnostic uncertainty with AD
 Spatial disorientation appears to be unique to AD,
but lacks sensitive diagnostic tests

Aims of the Study

*AD vs. bvFTD/SD/Control

 Develop an ecologically valid assessment of spatial
orientation for patients with dementia
 Compare spatial orientation performance in AD and
FTD
 Identify neural correlates of spatial orientation

(P < 0.05)

 ‘Total’ correct orientation based on 2 principal
directional components (front/back & left/right)
 Controls > AD on all components
 Controls > bvFTD only with ⇑ task difficulty
 Semantic FTD patients showed intact spatial
orientation

Structural Imaging * Grey matter brain changes in dementia patients compared to controls (FWE, P < 0.01)

Method






 Participants shown short videos moving
through a supermarket
 Explicitly asked to keep track of direction
 2 Sections with 7 trials each:
• (1) 7, 20s, 3 turns
• (2) 7, 40s, 5 turns

**bvFTD vs. Control

58 patients and 23 controls, matched for age & education
20 AD, 24 bvFTD, 14 SD
Cognitive assessment: ACE-R, RAVLT, RCFT, Digit Span
Assessed for spatial orientation on experimental task
High-resolution structural brain MRI analysed using voxelbased morphometry in FMRIB’s Software Library (FSL)

Neuropsychological Performance
AD

bvFTD

SD

Controls Group AD vs.
Effect bvFTD
(n = 23)

(n = 20)

(n = 24)

(n = 14)

Age (y.o)

66 (8)

65 (9.3)

65 (8)

67 (3.4)

n/s

n/s

Education (yrs)

12 (3.3)

12 (3.1)

13 (1.9)

13 (3.1)

n/s

n/s

Disease Duration (yrs)

6 (4.8)

6 (4.3)

6 (1.9)

n/a

n/s

n/s

63 (20.9)

96 (2.4)

*

*

19 (5.2)

14 (5.8)

24 (1.4)

*

*

9 (1.3)

8 (2.7)

9 (0.3)

*

*

-

54 (8.6)

*

*

 AD

 bvFTD

 SD

Neural Correlates of Spatial Orientation

ACE-R:
Total (/100) 70 (9.1) 82 (10.2)
Memory (/26) 12 (4.5)
Orientation (/10)

7 (2.1)

RAVLT:
T1-5 (/75) 25 (6.9) 36 (11.3)
30min Delay (/15)

1 (1.6)

6 (4.1)

-

11 (2.4)

*

*

Recognition (/15) 10 (2.8)

11 (2.5)

-

14 (1.3)

*

n/s

29 (5.6)

31 (2.6)

32 (3.4)

*

n/s

3 (3.5)

11 (7.8)

12 (7.3)

19 (8.2)

*

*

Forward (/16)

8 (1.9)

9 (1.6)

9 (2.6)

11 (2.3)

*

n/s

Backward (/14)

4 (1.4)

5 (1.7)

6 (2.1)

8 (2.8)

*

n/s

RCFT:
Copy (/36) 25 (7.7)
Delayed (/36)

 Retrosplenial cortex correlates with spatial
orientation performance

Digit Span:

* Indicates significance at P < 0.003

 Memory significantly impaired in AD and FTD
patients

Conclusions
1. The virtual supermarket task is a practical tool for assessing spatial orientation in dementia populations.
2. Patients with FTD show significant memory impairment, but preserved spatial orientation.
3. Spatial orientation is dependent on memory processes, but is subserved by retrosplenial regions rather than
the hippocampus.

Contact: s.tu@neura.edu.au






Download INMH 2014 poster



INMH_2014_poster.pdf (PDF, 676.26 KB)


Download PDF







Share this file on social networks



     





Link to this page



Permanent link

Use the permanent link to the download page to share your document on Facebook, Twitter, LinkedIn, or directly with a contact by e-Mail, Messenger, Whatsapp, Line..




Short link

Use the short link to share your document on Twitter or by text message (SMS)




HTML Code

Copy the following HTML code to share your document on a Website or Blog




QR Code to this page


QR Code link to PDF file INMH_2014_poster.pdf






This file has been shared publicly by a user of PDF Archive.
Document ID: 0000185978.
Report illicit content