Mitochondrial proteins .pdf
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The critical role of carbohydrate post translational modifications on cell surface proteins and those
bound to circulatory proteins is well recognized. Glycans on proteins mediate a host of biological events
including cell adhesion, immune system function, fertilization, cellular targeting as well as protein
transport, stabilization and half-life. It has also been established that o-beta-GlcNAc is a dynamic post
translational modification involved in more than 3,000 nuclear, cytoplasmic and mitochondrial proteins.
Sussex Research is a well known specialist in carbohydrate synthesis with an established international
reputation. Founded in 1996, Sussex Research is a carbohydrate-enabling company, excelling in the
design, synthesis and characterization of carbohydrate-based molecules. Our unique product portfolio
enables researchers across a variety of scientific disciplines to readily explore and exploit glycobiology
via facile introduction onto small molecules, biological molecules, nanoparticles or surfaces. Our
advanced capabilities in carbohydrate synthetic chemistry, purification and characterization has
benefited our collaborators in academia, research institutions, biotechnology and pharma at all stages of
research & development from basic research to clinical trials.
A modern carbohydrate portfolio:
Glycosylated amino acids, glycosylated peptides, glycosylated lipids, oligosaccharides, biotinylated
carbohydrates, carbohydrates with functional linkers/spacers, glucuronides, glycoconjugates,
Carbohydrate custom synthesis and contract research & development:
Sussex Research is highly active in custom synthesis, contract manufacture and contract research & development of
oligosaccharides, glycosaminoglycans, glycoamino acids, glycopeptides, modified carbohydrates with functionalized
linkers/spacers and a wide variety of synthetic building blocks. We routinely carry out carbohydrate synthesis,
oligosaccharide synthesis, glycan synthesis, glycoamino acid synthesis, glycopeptide synthesis, glycoconjugate synthesis,
glucuronide synthesis, glycan biotinylation, glycolipid synthesis, lipopolysaccharide synthesis, glycocongugation to carrier
proteins, custom synthesis and other projects.
Sussex Research is known worldwide for its custom synthesis and contract R&D capabilities which utilize
our core expertise in carbohydrate synthesis and method development. We provide custom synthesis
solutions for biopharmaceutical, therapeutic, diagnostic and research applications for development of
molecules that incorporate glycotechnology or exploit glycobiology. We excel at oligosaccharide,
glycopeptide and glycoconjugate synthesis. All materials produced at Sussex are thoroughly analyzed and
characterized on-site via a variety of state-of-the-art spectroscopic techniques including high field nmr
and mass spectrometry.
Sussex Research specializes in multi-step custom synthesis for researchers. We welcome projects which
utilize our core expertise in carbohydrate synthesis.
Sussex Research offers analytical and bioanalytical services on a fee-for-service basis – from
glycoanalysis in support of structure characterization to small molecule characterization and
bioanalytical analysis in support of drug discovery and research programs.
K. Brady Clark, Ph.D.
Sussex Research Laboratories Inc.
100 Sussex Drive, Suite 1120B
Canada K1A 0R6
Tel: (613) 993-4402
Fax: (613) 949-5993