Zorzela Liliane M 201501 PhD.pdf


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Table  of  Contents  
Chapter  1  
Thesis  Background  .......................................................................................................................................  2  
Systematic  reviews  ..................................................................................................................................  2  
The  need  to  improve  knowledge  synthesis  of  harms  ..............................................................................  2  
Improving  reporting  in  systematic  reviews  .............................................................................................  3  
Why  a  PRISMA  Harms  extension  is  important  .........................................................................................  3  
Clinical  context  ........................................................................................................................................  4  
Goal  of  this  doctoral  thesis  ..........................................................................................................................  4  
Thesis  Outline  ..............................................................................................................................................  5  
Improving  the  report  of  adverse  events  in  systematic  reviews  ...............................................................  5  
Improving  the  estimate  of  adverse  events  ..............................................................................................  5  
Manuscript  based  thesis  chapters  ...............................................................................................................  5  
Chapter  2:  Quality  of  reporting  in  systematic  reviews  of  adverse  events:  systematic  review  ................  5  
Chapter  3:  The  development  of  PRISMA  Harms  using  a  modified  Delphi  technique  ..............................  6  
Chapter  4:  PRISMA  Harms  .......................................................................................................................  6  
Chapter  5:  Propofol  infusion  for  paediatric  sedation  ..............................................................................  6  
References  ...................................................................................................................................................  7  
Chapter  2  
Quality  of  reporting  in  systematic  reviews  of  adverse  events:  systematic  review  ....................................  11  
Abstract  .................................................................................................................................................  12  
Introduction  ...............................................................................................................................................  13  
Methods  ....................................................................................................................................................  14  
Development  of  the  checklist  items  ......................................................................................................  14  
Search  strategy  ......................................................................................................................................  14  
Eligibility  criteria  ....................................................................................................................................  15  
Screening  and  data  extraction  ...............................................................................................................  15  
Outcome  ................................................................................................................................................  16  
Data  analysis  ..........................................................................................................................................  16  
Results  .......................................................................................................................................................  17  
Titles  and  abstracts  ............................................................................................................................  18  

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