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Review of Herb Forskolin Side Effects and Potential Benefits .pdf


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Forskolin Is A Highly Effective and Safe Weight Loss Supplement
Forskolin is a weight loss and bodybuilding herb supplement, which has gained some attention
in the market. It is alternatively marketed as Colforsin and Coleonol as well. It is an organic
compound derived from the tuberous roots of Indian Coleus plant. It seems to have gained
some visibility after it was featured by Dr Oz in one of his shows.
Indian Coleus plant has been used for medicinal purposes for centuries. As part of Ayurvedic
medicine(Ancient Indian medicine) tradition it was used for treating various heart conditions
including high blood pressure, chest pain(angina), painful urination, convulsions and respiratory
disorders such as asthma.Unfortunately very little science has gone behind the modern day
claims about medicinal benefits of this herb. It seems like today's opportunistic marketers do
not care about thorough research but start drumming up their campaigns at slightest hints of
what may be remotely effective.
To get back to the point, there was only one peer reviewed scientific study done about side
effects of forskolin which was published in scientific journal. This study showed significant
effects on overweight and obese men. It reduced body fat percentage and body fat mass. It also
increased lean bone mass and serum testosterone levels in overweight and obese men. One
should take notice that study was conducted only on men! Just one scientific study is definitely
not sufficient enough to establish credibility of a supplement product.

Forskolin activates enzyme adenylyl cyclase. This enzyme is involved in transmitting chemicals
signals from outside of a cell, through cell membrane to the inside of a cell. Subsequent effect is
increased level of chemical messenger called cyclic AMP(Adenosine monophosphate) or cAMP
in short. cAMP is an important messenger in many biological processes. It is responsible for
transferring effects of hormones like adrenaline, which can not pass through the cell

membranes, to inside of the cell. Subsequently it plays role in regulation of glycogen, sugar and
lipid metabolism. It is believed, because of this activation mechanism, it might be playing role in
decreasing body fat and increasing lean bone mass.
Although fat reduction and lean bone mass increasing pure forskolin side effects have not been
studied that extensively, one of the well observed effect of Forskolin is that as a vasodilator and
bronchodilator. It has been consistently observed to reduce blood pressure. It has been
observed to be effective at reducing asthma attacks. Given this, one has to be careful, when
using it as a weight loss supplement, because of you are taking blood pressure reducing
medicines like calcium channel blockers or beta blockers, Forskolin will work in conjunction
with those medicine and there will be additive effect of reduction in blood pressure and it could
turn out to be a serious issues. Just as high blood pressure is not good, a significantly low blood
pressure is not good either.
In lab studies in test-tubes an on animals it has been observed that Forskolin interacts with
melanin under skin and resulting effect is that of tanning! Don't be surprised if it is claimed that
the same miracle drug will loose weight, help build body and will do tanning at the same time
without going to the sun!!


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