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Lomupren1405 .pdf

Original filename: Lomupren1405.pdf
Title: edu.Drugs
Author: edudrugs.com

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Lomupren - General Information:



A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It
is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an
established asthmatic attack. [PubChem]

Lomupren - Pharmacology:


Lomupren - Interactions:


Lomupren inhibits degranulation of mast cells, subsequently preventing the release of histamine and slowreacting substance of anaphylaxis (SRS-A), mediators of type I allergic reactions. Lomupren also may
reduce the release of inflammatory leukotrienes. Lomupren may act by inhibiting calcium influx.



Drug Interaction During Pregnancy: Cromolyn sodium and isoproterenol were studied following
subcutaneous injections in pregnant mice. Cromolyn sodium alone in doses up to 540 mg/kg/day
(approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m2 basis)
did not cause significant increases in resorptions or major malformations. Isoproterenol alone at a dose of
2.7 mg/kg/day (approximately 7 times the maximum recommended daily inhalation dose in adults on a
mg/m2 basis) increased both resorptions and malformations. The addition of 540 mg/kg/day of cromolyn
sodium (approximately 340 times the maximum recommended daily inhalation dose in adults on a mg/m2
basis) to 2.7 mg/kg/day of isoproterenol (approximately 7 times the maximum recommended daily
inhalation dose in adults on a mg/m2 basis) appears to have increased the incidence of both resorptions
and malformations.

Lomupren - Contraindications:
Intal Inhaler is contraindicated in those patients who have shown hypersensitivity to cromolyn sodium or
other ingredients in this preparation.

Lomupren - Brand related:
Aarane, Alercom, Alerion, Allergocrom, Apo-Cromolyn, Children's Nasalcrom, Colimune, Crolom, Cromolyn

Nasal Solution, Cromoptic, Cromovet, Fivent, Gastrocrom, Gastrofrenal, Gen-Cromoglycate, Inostral, Intal,
Intal Inhaler, Intal Syncroner, Introl, Irtan, Lomudal, Lomupren, Lomusol, Lomuspray, Nalcrom, Nalcron,
Nasalcrom, Nasmil, Opticrom, Opticron, Rynacrom, Sofro, Vistacrom, Vividrin,

Lomupren - Indication:


Lomupren or cromolyn (USAN), a synthetic compound, inhibits antigen-induced bronchospasms and,
hence, is used to treat asthma and allergic rhinitis. Lomupren is used as an ophthalmic solution to treat
conjunctivitis and is taken orally to treat systemic mastocytosis and ulcerative colitis.

Lomupren - Generic Name:

Lomupren - Mechanism Of Action:





Lomupren - other paragraphs




Synonyms: Acide Cromoglicique [Inn-French]; Acido Cromoglicico [Inn-Spanish]; Acidum
Cromoglicicum [Inn-Latin]; Cromoglicic Acid; Cromoglycic Acid; Cromolyn; Cromoglycate
Drug Type: Small Molecule; Approved
Absorption: 1%
Toxicity: Symptoms of overdose include cough, nasal congestion, nausea, sneezing and wheezing.
Protein Binding: Not Available
Biotransformation: Not Available
Half Life: 1.3 hours
Dosage Forms Aerosol, metered Respiratory (inhalation)
Spray Nasal
Solution Ophthalmic
Capsule Oral
Solution Respiratory (inhalation)
Liquid Ophthalmic
Organisms Affected: Humans and other mammals

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