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Sample thesis CRISPR (1) .pdf



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Sample Thesis - Clustered regularly interspaced
short palindromic repeats (CRISPR)
by

Author
Submitted to the Chemistry
in partial fulfillment of the requirements for the degree of
Bachelors of Science
at the
MASSACHUSETTS INSTITUTE OF TECHNOLOGY
August 2018
c Massachusetts Institute of Technology 2018. All rights reserved.


Author . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Chemistry
June, 2018

Certified by . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Supervisor
Thesis Supervisor

Accepted by . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Chair
Chairman, Department Committee on Graduate Theses

2

Sample Thesis - Clustered regularly interspaced short
palindromic repeats (CRISPR)
by
Author
Submitted to the Chemistry
on June, 2018, in partial fulfillment of the
requirements for the degree of
Bachelors of Science

Abstract
A major addition to the understanding of CRISPR came with Jansen’s observation
that the prokaryote repeat cluster was accompanied by a set of homologous genes
that make up CRISPR-associated systems or cas genes. Four cas genes (cas 1 to
4) were initially recognized. The Cas proteins showed helicase and nuclease motifs,
suggesting a role in the dynamic structure of the CRISPR loci.[24] In this publication
the acronym CRISPR was coined as the universal name of this pattern. However, the
CRISPR function remained enigmatic.
Simplified diagram of a CRISPR locus. The three major components of a CRISPR
locus are shown: cas genes, a leader sequence, and a repeat-spacer array. Repeats
are shown as gray boxes and spacers are colored bars. The arrangement of the three
components is not always as shown.[1][3] In addition, several CRISPRs with similar
sequences can be present in a single genome, only one of which is associated with cas
genes.[8]

Thesis Supervisor: Supervisor
Title:

3

Sample Thesis - Clustered regularly interspaced short
palindromic repeats (CRISPR)
by
Author
Submitted to the Chemistry
on June, 2018, in partial fulfillment of the
requirements for the degree of
Bachelors of Science

Abstract
A major addition to the understanding of CRISPR came with Jansen’s observation
that the prokaryote repeat cluster was accompanied by a set of homologous genes
that make up CRISPR-associated systems or cas genes. Four cas genes (cas 1 to
4) were initially recognized. The Cas proteins showed helicase and nuclease motifs,
suggesting a role in the dynamic structure of the CRISPR loci.[24] In this publication
the acronym CRISPR was coined as the universal name of this pattern. However, the
CRISPR function remained enigmatic.
Simplified diagram of a CRISPR locus. The three major components of a CRISPR
locus are shown: cas genes, a leader sequence, and a repeat-spacer array. Repeats
are shown as gray boxes and spacers are colored bars. The arrangement of the three
components is not always as shown.[1][3] In addition, several CRISPRs with similar
sequences can be present in a single genome, only one of which is associated with cas
genes.[8]

Thesis Supervisor: Supervisor
Title:

3

4

Acknowledgments
To chair and co-chair of the department

5

6

Contents
1 Introduction

11

7

8


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