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University of Michigan Sample thesis document .pdf



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Sample Thesis - Clustered regularly interspaced
short palindromic repeats (CRISPR)

by
Typeset

A dissertation submitted in partial fulfillment
of the requirements for the degree of
Bachelors of Science
( Bioscience)
in The University of Michigan
2019

Doctoral Committee:
Chair , Chair
Co-Chair , Co-Chair
Member

c


Typeset

2017

All Rights Reserved

Dedicated to chair and co-chair of the department

ii

ACKNOWLEDGEMENTS

This research was supported/partially supported by Sample Biotech Foundation.
We thank our colleagues from the institute who provided insight and expertise that
greatly assisted the research, although they may not agree with all of the interpretations/conclusions of this paper.

iii

PREFACE

A major addition to the understanding of CRISPR came with Jansen’s observation
that the prokaryote repeat cluster was accompanied by a set of homologous genes that
make up CRISPR-associated systems or cas genes.

iv

TABLE OF CONTENTS

DEDICATION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

ii

ACKNOWLEDGEMENTS . . . . . . . . . . . . . . . . . . . . . . . . . .

iii

PREFACE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

iv

LIST OF FIGURES . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

vi

LIST OF ABBREVIATIONS . . . . . . . . . . . . . . . . . . . . . . . . .

vii

ABSTRACT . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

viii

CHAPTER
I. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

1

II. Overview . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

4

v

LIST OF FIGURES

Figure
1.1

. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

vi

2

LIST OF ABBREVIATIONS

vii

ABSTRACT

Sample Thesis - Clustered regularly interspaced short palindromic repeats
(CRISPR)
by
Typeset

Chair: Chair

Four cas genes (cas 1 to 4) were initially recognized. The Cas proteins showed helicase and nuclease motifs, suggesting a role in the dynamic structure of the CRISPR
loci.In this publication the acronym CRISPR was coined as the universal name of
this pattern. However, the CRISPR function remained enigmatic.

viii


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