Disorder of hypothalamus pituitary disorders .pdf
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Disorders of the Hypothalamic
– Pituitary Axis
Prof. AKM Musa
Head of Medicine
• Clinical features:
Growth hormone secretion is often the
earliest to be lost causinglethargy
Muscle weakness and increased fat mass
Impaired gonadotrophin (LH and FSH)
secretionin the male, loss of libido, gynaecomastia and
decreased frequency of shaving.
in the female, oligomenorrhoea or amenorrhoea.
ACTH deficiencyresulting in symptoms of
cortisol insufficiency including postural
TSH deficiencycauses secondary hypothyroidism.
This contributes apathy and cold