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Disorder of hypothalamus pituitary disorders .pdf


Original filename: Disorder of hypothalamus _ pituitary disorders.pdf
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ENDOCRINOLOGY
Disorders of the Hypothalamic
– Pituitary Axis
Prof. AKM Musa
Head of Medicine

Hypothalamic–Pituitary Axis

Cont.

Hypopituitarism
• Clinical features:
Growth hormone secretion is often the
earliest to be lost causinglethargy
Muscle weakness and increased fat mass
Impaired gonadotrophin (LH and FSH)
secretionin the male, loss of libido, gynaecomastia and
decreased frequency of shaving.
in the female, oligomenorrhoea or amenorrhoea.

ACTH deficiencyresulting in symptoms of
cortisol insufficiency including postural
hypotension.
TSH deficiencycauses secondary hypothyroidism.
This contributes apathy and cold
intolerance.


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