RHeumatoid arthritis .pdf
Original filename: RHeumatoid arthritis.pdf
Title: Slide 1
This PDF 1.5 document has been generated by Microsoft® PowerPoint® 2013, and has been sent on pdf-archive.com on 20/05/2017 at 17:30, from IP address 45.127.x.x.
The current document download page has been viewed 159 times.
File size: 14.5 MB (80 pages).
Privacy: public file
Download original PDF file
Dr.Khwaja Nazim Uddin
phenotype of RA is a
deforming, small and
The clinical course
is usually life-long,
Rheumatoid arthritis (RA) is the most common
inflammatory arthritis in women
In Caucasians it is around 1.0-1.5% with a
female:male ratio of 3:1.
Before the age of 45, the female:male ratio is
Prevalence increases with age, with 5% of
women and 2% of men over 55 years being
Even though infectious agents such as viruses, bacteria, and fungi
have long been suspected, the cause of rheumatoid arthritis is
Grading of function in RA
1: Fit for all activities-----------------no
11:Moderate restriction-independent despite
some limitation of joint movement
111: Marked restriction-limited self
care.Some assistanc required
1V :Confined to chair or bedbound largely
incapacitated and dependent
Autoimmunity: A is an autoimmune disease
Heredity: Disease is increased in first-degree relatives
HLA :-DR1 is more important in Indians and Israelis and
DW15 in Japanese.DR4 positivity more common in those
with severe erosive disease.
Sex:Female gender is a risk factor and this susceptibility
is increased post-partum and by breast feeding.
Infection: No infectious agents have been consistently
Smoking: Cigarette smoking is a risk factor for RA and for
positivity for rheumatoid factor in non-RA subjects.
RA is characterized by
persistent cellular activation
the presence of immune complexes at
sites of articular and extra-articular lesions
This leads to