chr pancreatitis complications .pdf
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DR. MD. MAMUNUR RASHID
ASSOCIATE PROFESSOR & HEAD
a. Exocrine: secrets digestive enzymes.
• About 98% of weight of pancreas
Water, HCO3 & Enzymes
b. Endocrine: Islets of Langerhans
About 2% of weight of pancreas
A Cell Glucagon
B Cell Insulin.
D Cell Somatostatin
(inhibition of insulin, glucagon & other secretions.)
Common Diseases of Pancreas
• True Cysts
Chronic inflammatory disease in which there is irreversible
progressive destruction of pancreatic tissue characterized by
functional loss and progressive fibrosis of the pancreas.
o 2-10 Per 100,000 population per year
oIn Kerala 1 per 793 inhabitant.
• Ductal obstruction - stone, tumour, stricture, malformation,
(annular pancreas, pancreatic divisum)
• Alcohol, tobacco,malnutrition, hypercalcaemia, hereditary
• Idiopathic (20-40%), Hereditary
Metabolic disorders (diabetes mellitus, haemachromatosis, hyper
Following any episode of acute pancreatitis
Pain radiating to the back, left shoulder
Nausea / vomiting.
Change of life style.
Increased incidence of diabetes mellitus
Increased incidence of pancreatic malignancy
• Clinical Examination
• Evaluation Of Pain (by pain scale)
• Selective Investigations:
Plain X-ray Abdomen.
CT Scan of HBS & Pancreas
MRCP (Magnetic Resonance Cholangio-Pancreatography)
Endocrine / Exocrine function test