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2017DBS Antibody Flyer 102017 web .pdf


Original filename: 2017DBS_Antibody_Flyer_102017_web.pdf
Title: 2017DBS_Antibody_Flyer_102017_web

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Expanding possibilities with

ANTIBODIES
Diagnostic BioSystems offers a wide range of ready-to-use and concentrated antibodies optimized
to provide high quality staining when used for immunohistochemical applications.
NKX3.1
NKX3.1 may prove to be a valuable marker to assist in
determining prostatic origin in poorly differentiated
metastatic carcinomas. NKX3.1 is more sensitive than
prostate specific antigen (PSA) for metastatic prostate
carcinoma. NKX3.1 has a 99.7% specificity for prostate and
its use in IHC is cited in the best practices recommendations for prostate in the International Society of Urologic
Pathology consensus conference.

Mesothelin

NKX3.1

Mesothelin is a valuable marker for pancreatic ductal
adenocarcinoma due to its strong reactivity in tumor tissue
and absence in normal pancreas. It has demonstrated
utility in the differential diagnosis between these primary
tumors and corresponding metastatic renal cell carcinoma
within the context of an antibody panel.

Mesothelin

Glypican 3
Glypican 3 is overexpressed in neoplastic liver tissue and
elevated in serum, but is undetectable in normal liver,
benign liver, and the serum of healthy donors. A high level
of Glypican 3 expression is also found in some types of
embryonal tumors such as Wilms’ tumor and hepatoblastoma. GPC3 is expressed significantly higher in follicular
carcinoma than that of follicular adenoma. In contrast,
GPC3 is not expressed in anaplastic carcinoma.

Mammaglobin

Glypican 3

Mammaglobin-A is highly overexpressed in breast
cancer cell lines and primary breast tumors. This
pattern of expression is restricted to mammary epithelium and metastatic breast tumors. Thus, MammaglobinA-specific T Cell immune responses may provide an
important approach for the design of breast cancerspecific immunotherapy.

Mammaglobin

Diagnostic BioSystems, Inc. | Pleasanton, CA 94588 | customersupport@dbiosys.com | T.888.896.3350 | F.925.484.3390 | dbiosys.com

MOC-31
MOC-31 antibody, also known as Epithelial Specific
Antigen/Ep-CAM, recognizes an epithelial-associated,
glycoprotein located on the cell membrane surface and in
the cytoplasm of virtually all epithelial cells. It is useful
in differentiating lung adenocarcinoma (+) and mesothelioma (-), as well as tumors of unknown origin in liver
cancers and distinguishing cholangiocarcinoma (+) from
hepatocellular carcinomas (-).

MyoD1

MOC-31

MyoD1 stains the nuclei of myoblasts in developing muscle
tissues. It is not detected in normal adult tissue but is
expressed strongly in the tumor cell nuclei of rhabdomyosarcoma. Rhabdomyosarcomas (RMS) are the most
frequent malignant soft tissue neoplasms of childhood.
MyoD1 can be used together with anti-myogenin and
anti-desmin as a panel of markers since any RMS is virtually
never negative for all three markers simultaneously.

MyoD1

HSV 1 and 2
HSV 1 and 2 reacts with HSV type 1 and 2 specific antigens
and with antigens common to HSV type 1 and 2 virus. It
reacts with all the major glycoproteins present in the viral
envelope as well as with at least one core protein.

WT1

HSV 1 and 2

The WT1 gene is normally expressed in fetal kidney and
mesothelium. WT1 has been demonstrated in Wilms’
tumors and in the majority of mesotheliomas. It is an aid
in the identification of WT1 protein over-expression in
mesothelioma, ovarian carcinoma and Wilms’ tumor
within the context of an antibody panel. It has also been
identified in proliferative mesothelial cells, gonadoblastoma, nephroblastoma, and desmoplastic small round
cell tumor.

WT1

Fascin-1
Fascin-1 is a sensitive marker for Reed-Sternberg cells of
Hodgkin's Disease and a helpful marker to distinguish
between Hodgkin Lymphoma and non-Hodgkin Lymphoma in difficult cases. Fascin-1 is also a prognostic marker in
high-grade serous ovarian carcinoma.

Elastin

Fascin-1

Elastin is an important polymeric protein of connective
tissue that imparts elasticity to vertebrate elastic
tissues. Haploinsufficiency of Elastin may be the cause
of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. It is also suggested to be a
novel marker in testicular germ cell tumors.

Elastin

Diagnostic BioSystems, Inc. | Pleasanton, CA 94588 | customersupport@dbiosys.com | T.888.896.3350 | F.925.484.3390 | dbiosys.com


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