Antigen Peptides .pdf
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Peptide antigen, namely, a peptide used to trigger animal's immune system to develop antibodies specific to that
peptide. Nowadays, the use of synthetic peptide antigens as immunogens has markedly increased, and this
technique is also widely applied for immune research such as tumor immunotherapy etc. With ten years experience
in antigen peptides supply, Creative Peptides is experienced in the synthesis of complex antigen peptides, such as
glycopeptides or hyperphosphorylation peptides.
Design of peptide antigens
Although many peptide sequences are immunogenic, not all of them are identically effective in generating antibodies
when act against the target protein. Effective antibody generation depends on several factors that need to be
considered at the very first stage of peptides designing.
Mimicking specific parts of the target protein, peptide antigens can provide much flexibility for scientific research.
However, most of synthetic peptides are composed of 10AA -25 AA, which are too short to generate a strong
immune response without prior conjugation to a carrier protein such as Keyhole Limpet Hemocyanin(KLH),
Ovalbumin(OVA) or Thyroglobulin(Tg). Creative peptides specialists can help with antigen design to maximize the
chances that the peptide used as antigen can generate sufficient and effective antibody.
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