抗癌药品多柔比星注射剂药物相互作用 .pdf

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抗癌药品多柔比星注射剂药物相互作用
多柔比星药物相互作用
1.各种骨髓抑制剂特别是亚硝脲类、大剂量环磷酰胺或甲氨蝶呤、丝裂霉素或放射治疗,
如与该品同用,后者一次量与总剂量均应酌减。
2.该品如与链佐星(streptozotocin)同用,后者可延长该品的半衰期,因此前者剂量应予酌
减。
3.任何可能导致肝脏损害的药物如与该品同用,可增加该品的肝毒性;与肝素、头孢菌素
等混合应用易产生沉淀。
4.该品与柔红霉素呈交叉耐药性。与甲氨蝶呤、氟尿嘧啶、阿糖胞苷、氮芥、丝裂霉素、
博来霉素、环磷酰胺以及亚硝脲类等则不呈交叉耐药性,且与环磷酰胺、氟尿嘧啶、甲氨
蝶呤、顺铂以及亚硝脲类药物同用,有不同程度的协同作用。
5.用药期间慎用活病毒疫苗接种。
6.该品可降低肝素抗凝作用。ACD 及普卡霉素与该品同用,有可能导致致死性心脏毒性;
该品与普萘洛尔合用,可加强抑制线粒体呼吸酶活性,增加心脏毒性。
印度抗癌药品更多详情咨询
电话:0091-9205113743
电子邮箱:lifesmarthealthcare@gmail.com
官网:www.apolopharmacy.com


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