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Allogeneic hematopoietic stem cell
transplantation in patients
with acute myeloid leukemia
a personalized approach
Jurjen Versluis
Allogeneic hematopoietic stem cell
transplantation in patients
with acute myeloid leukemia
a personalized approach
Jurjen Versluis
Allogeneic Hematopoietic Stem Cell Transplantation in patients with Acute Myeloid
Leukemia a personalized approach
Copyright © 2017 Jurjen Versluis, Rotterdam, The Netherlands.
All rights reserved.
No part of this thesis may be reproduced, stored in a retrieval system or transmitted
in any form or by any means without permission from the author. The copyright of
articles that have been published or accepted for publication has been transferred to the
respective journals.
ISBN: 978-94-92683-892-7795
Layout: Egied Simons
Cover: Egied Simons
Printing: Optima Grafische Communicatie, Rotterdam, the Netherlands
The work described in this thesis was performed at the Department of Hematology at the
Erasmus Medical Center Cancer Institute, Erasmus University Medical Center, Rotterdam,
the Netherlands.
Printing of this thesis was financially supported by Chipsoft, Abbott, Celgene, Amphia
Hospital Breda, and Erasmus University Rotterdam.
Allogeneic Hematopoietic Stem Cell Transplantation
in patients with Acute Myeloid Leukemia
a personalized approach
Allogene hematopoïetische stamcel transplantatie
voor patiënten met acute myeloïde leukemie
een gepersonaliseerde benadering
Proefschrift
ter verkrijging van de graad van doctor aan de
Erasmus Universiteit Rotterdam
op gezag van de
rector magnificus
Prof.dr. H.A.P. Pols
en volgens besluit van het College voor Promoties
De openbare verdediging zal plaatsvinden op
vrijdag 29 september 2017 om 13:30 uur
Jurjen Versluis
geboren te Asperen
PromotieCommissie
Promotor:
Prof. dr. J.J. Cornelissen
Overige leden: Prof. dr. P. Sonneveld
Prof. dr. B. Löwenberg
Prof. dr. G. Ossenkoppele
The eye sees all, but the mind shows us what we want te see.
William Shakespeare
Contents
Chapter 1: General introduction and outline of the thesis
Chapter 2: Comparative therapeutic value of post-remission approaches in
patients with acute myeloid leukemia aged 40–60 years
9
27
Chapter 3: Post-remission treatment with allogeneic stem cell transplantation
in patients aged 60 years and older with acute myeloid leukaemia:
a time-dependent analysis
55
Chapter 4: Comparative value of post-remission treatment in cytogenetically
normal AML subclassified by NPM1 and FLT3-ITD allelic ratio
79
Chapter 5: Graft versus leukemia effect of allogeneic stem cell transplantation
and minimal residual disease in patients with AML in first CR
103
Chapter 6: Alternative donors for allogeneic hematopoietic stem cell
transplantation in poor risk AML in CR1
129
Chapter 7: Prediction of non-relapse mortality in recipients of reduced intensity
conditioning allogeneic stem cell transplantation with AML in first
complete remission
151
Chapter 8: Hepatitis E virus: an underestimated opportunistic pathogen in
recipients of allogeneic hematopoietic stem cell transplantation
169
Chapter 9: General discussion
Addendum: Summary
Nederlandse samenvatting
Dankwoord (acknowledgements)
Curriculum vitae
List of publications and co-authors
PhD portfolio
189
217
221
227
231
233
237
Jurjen-Versluis.pdf (PDF, 17.88 MB)
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