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What Makes CBD an Efficient
On CBDMyth, we’ve been receiving a relatively high volume of emails lately. Every one
in five emails is a request from someone asking whether CBD can reduce pain completely.
After reading all these emails, I’ve decided to churn out a new article – one that pivots
around how CBD relieves pain, the science behind it, and what consumers should
realistically expect from this magic herb oil.
Reason behind body pain
Pain in the body is not a disease in itself, it’s rather a symptom indicating something
is wrong with your health. The parts of the body most susceptible to pain are muscles
and bones. You can have pain in glands and veins too, but it’s a bit unusual as most
people suffer from either muscle or joint pain.
How CBD treats pain
Marijuana, even addictive, is used in medical field. There have been anecdotal as
well as scientific evidence confirming CBD’s usefulness in the treatment of pain.
What makes CBD an efficient pain-reliever? CBD is a compound that binds with a
specific group of endocannabinoid receptors. The receptors are triggered to release
neurotransmitters that numb the body’s natural capacity to receive pain.
Research has shown most pains are neuropathic in nature and tampering with the
nerve pathways can block or minimize the sensation of pain.
Is CBD like analgesic?
Analgesia is not intrinsic to CBD, but it shares borders with analgesic drugs.
Randomized clinical trials conducted under the supervision of medical teams found
CBD’s mechanism mimics that of analgesic. The difference is analgesic drugs don’t
stimulate the CB1 and CB2 receptors, something that’s typically done by CBD and
other compounds found in cannabis.
Observing CBD’s unique pain relieving characteristics, scientists assigned a name to
the underlying mechanism. The name is cannabinoid analgesia. It’s a term that refers
to cannabinoid induced analgesia.
The science, in nutshell
The most well-researched cannabinoid type is called 21-carbon terpenophenolic. It’s
a naturally occurring cannabinoid type and phytocannabinoids genus of cannabis
plant is its source. All its compounds are nalgesic, but not equally good at that.
Tetrahydrocannabinol or THC is the strongest. One the flipside, it makes people
THC is a major phytocannabinoid. Its activities are supplemented and to some extent,
kept in check by other phytocannabinoids like CBD, Flavonoids and Terpenoids.
Scientists have synthesized these cannabinoids in clinical trials. The end result is
CBD products, low in THC and high in CBD, retaining THC’s analgesic qualities sans
the intoxicating effect .
Effect on cannabinoid receptor
Mammalian brains possess a minimum of two cannabinoid receptors. These are
called CB1 and CB2 receptors. CB1 receptors involve neurons in the central and
peripheral nervous system. CB2 receptors are made of non-neuronal tissues in these
CBD binds to CB1 receptors via allosteric enzyme. But it binds directly to CB2
receptors. This way, cannabinoid induced antinociception is produced.
Antinociception plays an important role in pain reduction – the kind of pain that
affects not only humans but all animals. According to research, if chronic pain is
caused by nerve damage or anti-inflammatory drugs, antinociception can suppress it
Cannabinoid receptors in the central and peripheral pathways are distributed.
Scientists are now studying these receptors to understand how cannabinoid engenders
antinociception. Hopefully, their research will shed new light onto CBD’s
effectiveness in treating hard-to-treat pain.
Alternative to painkillers
CBD products – be them edible oil or salve – can be a great alternative to NSAID drugs
or painkillers. Both are harmful to the body. Doctors sometimes dismiss these drugs
calling them unfit for human consumption.
Another reason CBD is a viable alternative to OTC painkillers is it gradually eliminates
pain completely. Painkillers, even though work quickly, don’t treat the root cause of the
pain. As a result, the pain comes back when the effect of the drug is over.
Is pain really physical?
Insights obtained from research into CBD leads to an important question. Is pain
completely physical or partly psychological? Oftentimes, the physiological factors
leading to pain disappear but the pain still remains.
How’s that possible? One credible explanation is the neural pathways responsible for
pain might continue to send signal even after an injury or a wound heals. This way,
people continue to suffer from pain.
When CBD works on the endocannabinoid receptors, it eliminates the
neuropathological factors contributing to pain. This is how, CBD cures physiological as
well as psychological factors associating to pain.
An endocannabinoid modulator
THC and CBD share a number of neuroprotective characteristics. CBD however, is an
endocannabinoid modulator unlike THC as the latter doesn’t bind to vanilloid receptors.
CBD being a TRPV1 agonist, inhibits a number of enzymes including fatty acid
amidohydrolase and hydrolytic enzyme.
It’s clear from the discussion above that CBD is way different from painkillers available in
the market. Not only it doesn’t have any harmful effect, but it actively restores the body’s
normal functioning so that it heals the wound/injury itself and get rid of the pain once and
forever. So, next time your back or shoulder aches, do give CBD a chance.
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