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Monoclonal Antibody Sequencing .pdf



Original filename: Monoclonal Antibody Sequencing.pdf
Title: Monoclonal Antibody Sequencing
Author: http://www.synbio-tech.com/services/antibody-service/monoclonal-antibody-sequencing/

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Monoclonal Antibody Sequencing

Obtaining the hybridoma monoclonal antibody (mAb) sequence is one of the key
requirements of recombinant antibody engineering. Synbio Technologies provides
both accurate and efficient monoclonal antibody sequencing services. To
accomplish this, we utilize special primer sets and advanced sequencing techniques
to help our customers to save on research costs and increase overall efficiency. In
doing so, we allow our customers to accomplish their downstream research goals
and applications such as antibody humanization, antibody reformatting or cell line
transfection.
Synbio Technologies’ standard monoclonal antibody sequencing service involves the
sequencing of 10-50 independent clones of the target mAb. With our extensive
experience, we can accurately measure the hybridoma mAb to generate a strong
consensus genetic sequence. Using the resulting sequences, the corresponding
antibodies can be obtained through recombinant proteins. Moreover you could
store your antibodies in the form of literal sequence information and prevent the
loss caused by the abnormal hybridoma.
Synbio Technologies offers the monoclonal antibody sequencing service designed to
generate accurate and reliable mAb genetic sequences. In addition, our engineered
antibody expression services utilize our NG™ Codon Optimization Technology and
Syno® Synthesis Platform. Both are beneficial to researchers interested in antibody
expression and purification for subsequent use.

Advantages
 Utilizing the RACE technology to obtain the complete monoclonal antibody
sequence information
 Using custom primer sets and special reagents developed by Synbio
Technologies to ensure optimal success rates and efficient turnaround times
Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

 Enhanced bioinformatic analysis removes redundant sequence information
 Full traceability ensures batch to batch consistency throughout our customers’
research development and manufacturing procedure
 The third party offers verification for your target antibody cell lines to ensure
strict quality control measures and added security

Applications
 Provide accurate antibody sequencing to support and strengthen your patent
application
 Permanently store monoclonal antibody sequences and prevent the loss of
hybridomas/cell lines
 Help the selection of appropriate cell lines to express recombinant monoclonal
antibody with higher purity
 Shorten the period of hybridoma clone and accelerate the generation of
monoclonal antibody
 Affinity maturation, further enhance the affinity of monoclonal antibody
 Build chimeric antibodies, humanized antibodies, bi-specific antibodies, etc.

Services Specifications
Service Description
Standard mAb
Sequencing

Standardized work
flow for
hybridoma
sequencing

Turnaround
Time

Deliverables

2-3 Weeks

1.Final sequence report
with leader sequences
and CDR region
annotated

Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

Express mAb
Sequencing

Rapidly identify
antibody
sequences from
the target cell lines

1 Week

2.Plasmid contains
antibody coding
sequence (u
pon your request)

*For antibody sequencing services: customers will need to submit hybridoma cell
samples (>1×106 cells) and indicate the subtype of your monoclonal antibody.

Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com


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