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Single B Cell Antibody Service .pdf


Original filename: Single B Cell Antibody Service.pdf
Title: Single B Cell Antibody Service
Author: http://www.synbio-tech.com/services/single-b-cell-antibody-service/

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Single B Cell Antibody Service

The immune system is a very robust “antibody factory” that consistently produces
antibodies to fight infections and diseases by recognizing and targeting infected
cells or pathogens (antigens). The emergence of single B cell antibody technology
has enabled a new strategy for discovery of naturally occurring antibody drugs. The
single B cell antibody technology produces higher throughput and higher coverage
than the conventional hybridoma or phage display technologies. Most importantly,
this technology also avoids the disadvantage of unnaturally paired heavy and light
antibody chain displayed by phage.
With our advanced technology and professional team, we have developed two
methods for discovering single B cell antibodies. The first method is based on the
antigen-specific single B cells sorting by Fluorescence Activated Cell Sorter (FACS),
followed by RT-PCR amplification to obtain the target antibody sequence. The
second method relies on the use of micromanipulators to select a single B cell of
interest, then culturing the cell for further characterization. With these two
complementary methods and our other custom antibody discovery services, we
help our customers effectively find antibody drugs while saving both time and
money.

Competitive Advantages





Micromanipulator-Based Single Cell Sorting Technology
Single Cell Culture Platform
Experienced R&D Team
Time Efficient and Cost Effective

Standard Process

Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

Service Specification
Details

Deliverables

Immunization
Single cell sorting

1.

Antibody humanization/ Antibody
affinity maturation (Optional)

Antibody sequence and
corresponding analysis report
2. Top 1-3 of optimal antibody
3. Full report (PDF)

Antibody production and characterization

Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com


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