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Single Domain Antibody (sdAb) Service .pdf



Original filename: Single Domain Antibody (sdAb) Service.pdf
Title: Single Domain Antibody (sdAb) Service
Author: http://www.synbio-tech.com/services/single-domain-antibody-service/

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Single Domain Antibody (sdAb) Service

Complex structures and high production costs associated with monoclonal
antibodies (mAbs) have limited their achievable clinical applications. For this reason,
scientists focusing on antibody drug discovery have shifted their interests toward
recombinant antibody fragments.
Recombinant antibodies, such as single domain antibodies (sdAb), are a new
generation of engineered antibody fragment that consisted of a single monomeric
variable antibody domain. sdAb is derived from camelid heavy chain antibodies
which lack the light chain and CH domain of the heavy chain in the conventional Fab
region. Therefore sdAb is smaller, more soluble and has higher stabilities than
conventional antibody. sdAb also features higher permeability, lower
immunogenicity and both simple and cost-effective production procedures. These
advantages have made it possible for sdAb to have a broader range of applications
within the biotechnology, pharmaceutical and immuno-therapeutic industries.
Based on Synbio Technologies’ extensive expertise in sdAb and advanced sdAb
discovery technology, we can provide our customers with a comprehensive one stop
solution from antigen production to specific recombinant sdAb expression.

Competitive Advantages
 Experienced antibody production team
 Proprietary Universal AntigenTM immunization technology
 Robust phage-display technology platform
 Advanced yeast-display technology platform (Large library capacity: ~ 109)
 Cost effective and milestone payment scheme
Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

Standard Process

Service Specification
Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

Milestones
Camel immunization (eg.
dromedaries, camels, llamas, and
alpacas)
PBMC isolation & immune
library construction
Screening of phage-displayed
library
Functional assay for sdAb
Large scale sdAb expression by
yeast
(followed by properties
identification)

Standard Deliverables

A glycerol stock of
sdAb expressing
bacteria (TG1)
2. Phage-displayed sdAb
library
3. Top 5 identified sdAb
strain and
corresponding
sequences
4. Full reports (PDF)

1.

Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Turnaround
Time
(Business day)

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

10 – 11 Months


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