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Yeast Genome Editing .pdf



Original filename: Yeast Genome Editing.pdf
Title: Yeast Genome Editing
Author: http://www.synbio-tech.com/services/crispr-cas9/yeast-genome-editing/

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Yeast Genome Editing
Yeast Genome Editing
With the advancement of genome editing technology, more and more species can
be genetically modified to satisfy a variety of requirements. Yeast is one of them.
Yeasts are unicellular fungi and have been making contributions to human society
from ancient times to the modern world. Apart from the applications in baking and
fermentation for thousands of years, yeast has also become an important model
organism in contemporary cell biology and microbiology research. Recently, the
CRISPR-Cas9 system has been used as an easy and cost-efficient method of
genome modification in simple model organisms. Genome editing in yeast can help
to produce efficient mutant yeast colonies and therefore promote their applications
in different industries such as biopharmaceuticals, pollution control, energy,
chemical bio-manufacturing, et cetera.
On the basis of genotype and phenotype, the innovative “GPS” platform created by
Synbio Technologies introduces Synotype, the gene synthesis, providing a one-stop
platform for highly accurate editing and modification of the yeast genome.

Yeast Genome Editing Service Advantages
 Efficient Genome Editing Tool: Edit any gene at any locus with high accuracy.
 Multiple Sites Mutant: Genes can be modified in multiple sites simultaneously.
 Fast Turnaround Time: 4-5 Weeks

Yeast Genome Editing Case Study
The ADE1 gene controls expression of adenine in yeast. ade1 mutant yeast were
engineered through CRISPR-Cas9. These mutants exhibited an accumulation of red
pigment, a phenotype associated with a lack of adenine.

Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

Fig.1. Pink yeast colonies which were programmed by CRISPR-Cas9 gene
modification.

Fig.2 DNA sequencing
DNA sequencing indicates that 21 base pairs were missing (fig.2), suggesting
successful gene modification

Service Specifications
Services

Information requested from
clients

Delivery
contents

Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

Turnaround
time



Yeast gene
knock-out services





Yeast gene
knock-in and
replacement
services





Strain that needs to be
modified along with strain
information.
Information of the knock-out
gene along with knock-out
sequences.
Strain that needs to be
modified along with strain
information.
Information about the
knock-in gene along with
sequences.
Knock-in sites and
replacement sequences.

Modified
glycerol
Yeast and
QC report

4-5 weeks

Modified
glycerol
Yeast and
QC report

4-5 weeks

Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com


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