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Oligo Modification & Labeling .pdf



Original filename: Oligo Modification & Labeling.pdf
Title: Oligo Modification & Labeling
Author: http://www.synbio-tech.com/services/oligo-modification-labeling/

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Oligo Modification & Labeling

Synbio Technologies provides comprehensive modifications and labeling services to
meet our customer’s specified research requirements. Our industry leading
professional team utilizes state-of-the-art synthesizers to achieve both oligo
synthesis and modifications. Our stringent quality control guidelines ensure the
synthesis of high-quality modified oligos and subsequently delivered in a timely
manner. In doing so, we will assist you with various research needs in biology,
diagnostics, personal medicine, drug discovery, etc.
Synbio Technologies’ custom DNA oligos are designed and synthesized with
rigorous quality control to ensure that overall quality while meeting our customers’
every request. Our specialized services include oligonucleotides modified with
special bases, dU/dI, phosphorothioates, phosphorylation, spacers, amino linkers,
disulfide linkers, biotin, digoxin, etc. Synbio Technologies also provides multiple
fluorescent groups and quenchers at 3’, 5’ or designated sites specified by the
customer. This includes FAM, HEX, ROX, BHQ and Texas Red, etc. The resulting
oligos can be used in a variety of applications, including PCR, cloning, sequence
verification, and gene detection.

Competitive Advantages

Comprehensive Modifications and Labeling:
Large-scale sequencing verifying the average mutation rate to be lower than
1/1000

Stringent ISO9001:
2015 Certified Processing for oligo synthesis, meticulously monitored and advanced
traceability


Multiple Purification Options:

Include desalt, PAGEE Plus, PAGEE, RP-HPLC, IE-HPLC and Dual HPLC

Technical Support:
Professional teams experienced in oligo synthesis and various modifications offer
support throughout the production progress
Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

Service Specifications

Classifications

Modifications

Purification
(10-45bp)

(46-80bp)

RP-HPLC

PAGE&RP-HPLC

dU
Modified Bases

dI
5-Methyl dC
5’ DBCO

DBCO

3’ DBCO

RP-HPLC
RP-HPLC

dT-DBCO
5’ AMCA
AMCA

3’ AMCA

RP-HPLC
RP-HPLC

dT-AMCA
Phosphorothioates

SPO3

PAGE&RP-HPLC

RP-HPLC

PAGE&RP-HPLC
PAGE&RP-HPLC

5’Amino C6
Amino Linkers

dT-Amino C6
3’Amino C7

RP-HPLC

5’Amino C12
Biotin

5’Biotin
3’Biotin

RP-HPLC
RP-HPLC

Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

PAGE&RP-HPLC

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

RP-HPLC
PAGE&RP-HPLC

dT-Biotin
5’Digoxigenin
Digoxigenin

3’Digoxigenin

RP-HPLC
RP-HPLC

PAGE&RP-HPLC

dT-Digoxigenin
5’ PO4

Phosphorylation

RP-HPLC

3’ PO4
5’ HS-C6

Hydrosulphonyl

3’ HS-C3

PAGE&RP-HPLC
RP-HPLC

RP-HPLC

PAGE&RP-HPLC

Locked Nuleic Acid

LNA (A/G/C/U)

RP-HPLC

PAGE&RP-HPLC

Fluoro Bases

2’-F-2’-dA
2’-F-2’-dC
2’-F-2’-dG
2’-F-2’-dU

RP-HPLC

PAGE&RP-HPLC

RP-HPLC

PAGE&RP-HPLC

dSpacer
Spacer C3

Spacer

Spacer C9
Spacer C18

Purification

Dye/Quenchers 3’- 5’- Designated sites
FAM







TET







JOE







HEX







(10-45bp)

(46-80bp)

RP-HPLC

RP-HPLC/Dual RP-HPLC

Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

SIMA







TAMRA







ROX







Cy5







Cy3







Quasar670





Quasar570





DyLight547



DyLight647



Texas Red



BHQ-1



BHQ-2



BHQ-3



Eclipse



DABCYL



Dyes

RP-HPLC

Dual RP-HPLC

Quenchers
3’TAMRA

5’6-FAM

Purification
(10-45bp)
Dual RP-HPLC

3’BHQ-1
3’Eclipse

(46-80bp)

RP-HPLC & IE-HPLC

RP-HPLC & IE-HPLC

3’DABCYL
5’TET

3’TAMRA

Dual RP-HPLC

RP-HPLC & IE-HPLC

Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

3’BHQ-2
3’DABCYL
3’TAMRA
5’HEX

RP-HPLC & IE-HPLC
Dual RP-HPLC

3’BHQ-1
3’BHQ-2

RP-HPLC & IE-HPLC

RP-HPLC & IE-HPLC

3’DABCYL
3’Eclipse
5’TAMRA

3’BHQ-1
3’BHQ-2

RP-HPLC & IE-HPLC

RP-HPLC & IE-HPLC

RP-HPLC & IE-HPLC

RP-HPLC & IE-HPLC

RP-HPLC & IE-HPLC

RP-HPLC & IE-HPLC

3’DABCYL
3’Eclipse
5’ROX

3’BHQ-1
3’BHQ-2
3’DABCYL
3’BHQ-1

5’CY5

3’BHQ-2
3’BHQ-3
3’DABCYL

5’CY3

3’BHQ-2
3’Eclipse
3’BHQ-1

5’JOE

3’BHQ-2

RP-HPLC & IE-HPLC

RP-HPLC & IE-HPLC

3’DABCYL
5’Texas Red

3’TAMRA

Dual RP-HPLC

3’BHQ-2

RP-HPLC & IE-HPLC

RP-HPLC & IE-HPLC

Standard Deliverables
Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com

 Lyophilized dry DNA oligo powder
 1 tube (Transparent or dark) or 96-well and 384-well plate
 Certificate of Analysis (COA) including sequencing information, OD, Tm, etc.

Contact us
Synbio Technologies
1 Deer Park Drive, Suite L-1
Monmouth Junction
NJ, 08852

Tel:+1 732-230-3003
Fax:+1 609 228 5911
Web:www.synbio-tech.com
E-mail:service@synbio-tech.com


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