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PRIMARY CELLS
VS.
CELL LINES
Creative Bioarray
A Division Of Creative Dynamics Inc

WHAT IS
PRIMARY CELL?
Primary cells are cells taken directly from living
tissue and established for growth in vitro.
These cells are retaining of the main natural
functional of the tissue.
Generally, they retain normal morphology, cellular
function, growth characteristics, cellular markers,
signaling and genetic integrity when propagated in
culture.

Creative Bioarray
A Division Of Creative Dynamics
Inc

CELL LINES PROFILE


Cells that have been continually
passaged over a long period of time.



Cell lines can be finite or continuous.



They are preferably used for convenience
as they are easy to handle and widely
published



However, these cells less preferred as a
biologically relevant option, since they
have lost the true characteristics of the
original tissue from which they were
isolated.

Creative Bioarray
A Division Of Creative Dynamics
Inc

The Major Differences Between Primary Cells and Cell Lines
Primary Cells

Cell Lines

Limited

Indefinite

In Vivo Conditions

Yes

No

Chromosomal Aberrations

Minimal

Several

Cell Division In Vitro
More Closely Mimic

Provide High Quality Data on
Interactive Pathways,
Processes, and Function

Authentication required
before use

Care and Maintenance of
the Cells

Retain functional enzymatic and

signaling pathways of parent tissue
No, if bought commercially
Can be complex and difficult,
especially in maintaining
differentiated state

Potentially provide misleading data
due to aberrant enzymatic or
signaling pathway activities

Yes, mandated by many government
institutes and scientific journals
Easy to maintain or propagate



With the development of technology, the primary cell culture has changed.
New tools, new approach.

Creative Bioarray
A Division Of Creative Dynamics
Inc

Primary cell types: They’re the real deal!

Using a well-characterized,
terminally differentiated cell
type can deliver confidence
and assurance in data
generated in vitro.
Entrusting biomedical
research to verified or
more thoroughly
characterized cell culture
tools will deliver the most
meaningful and
trustworthy experimental
results short of performing

Knowing the “how &
where” of the cells and
support materials is
crucial.
Cost to use, maintenance
in culture, and other
unique challenges
associated with primary
cells should be considered.

Some of the applications where primary cells are being
used


Cellular pathway analysis



ADME & toxicology studies



Regenerative medicine



Adult stem cells



Metabolic disease research



Comparative studies vs. transformed cell lines



HTS/HCA screening



Other platforms

Commercial primary cell providers

——Creative Bioarray



35 human cell systems with over 160 different cell types



Over 13 types of other animals & A selection of primary
cells of animals for comparative testing



Creative Bioarray

A Division Of Creative Dynamics Inc

Also provide related services to meet specific client
requirements



Strict quality control and supply whole information with
each of our products

USA
 

 COMPANY:
 PHONE:
 FAX:

CREATIVE BIOARRAY
1-631-626-9181

1-631-614-7828

 ADDRESS:
45-1 RAMSEY ROAD, SHIRLEY,
NY 11967, USA
 EMAIL:
INFO@CREATIVEBIOARRAY.COM
 

 EUROPE
 

 COMPANY:
 PHONE:

CREATIVE BIOARRAY
44-207-097-1828

 EMAIL:
INFO@CREATIVEBIOARRAY.COM

Looking forward to cooperating with you!


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