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Tadalafil bulk supplier CAS 171596-29-5 dosage, side
Erectile dysfunction (ED) has become a common health issue amongst men, especially
those who’ve hit 40. A recent research shows that 5% of men aged 40 years suffer from
complete erectile dysfunction. The percentage increases to 15 for 70 years-old men. To
address this problem, scientists have come up with various medications aimed at helping
men maintain their masculinity with proper erection capability. Tadalafil (CAS 171596-29-5)
is one of the most prominent ED treatment medications.
What is Tadalafil (171596-29-5)?
♦ Brand name: Cialis, Adcirca, etc.
♦ Chemical structure of Tadalafil
Tadalafil is a FIDA-approved oral drug used for the treatment of erectile dysfunction or
impotence among men. It functions similarly to similar to Viagra and Levitra by increasing
the flow of blood to the penis and as a result, enables a man to get an erection. It is
suitable for adult men who have difficulties in attaining or maintaining a penile erection.
♦ Tadalafil history
Galxo Wellcome, in collaboration with Lilly ICOS, a biotechnology company, was the first
to discover and develop Tadalafil. However, the companies parted ways in 1996 and two
years later, ICOS Corporation and Eli Lilly entered a joint venture and formed a new
company called Lilly ICOS, LLC. The venture developed the drug again and started to sell
it as Cialis.
After a few years, Lilly ICOS, LLC. filed a new application for the drug with Tadalafil as the
generic name and Cialis as the brand name. December 2003 was a historic moment for
Tadalafil as it is the time that it was approved by the Food and Drug Administration (FDA)
for sale in the United States as a drug for erectile dysfunction treatment.
Tadalafil powder video
Tadalafil (171596-29-5) — How does it work?
Men with ED usually have an enzyme called PDE5. This enzyme suppresses cyclic
guanosine monophosphate (cGMP), an extremely important substance in the processing
of a healthy penile erection. cGMP helps a man’s nerve ending signals in the pelvic
region to trigger nitric oxide release. As a result, the smooth linings of his pelvic blood
vessels relax and this leads to increased blood flow through the vessels to fill the
cavernous structures of his penile body. This makes the penis to become hard and
Higher amounts of PDE5 and insufficient cGMP in a man make his body unable to
decipher the signals released by his nerve endings, leading to partial or complete loss of
ability to get a penile erection. Men with erection problems have low blood flow to their
penises. Since a penis becomes hard as a result of increased supply, such men cannot
get an erection due to lack of insufficient blood in their penises.
When a man with penile erection incapability takes Tadalafil (171596-29-5) as prescribed,
the drug reduces the effects of PDE5 in his body system and this makes cGMP
concentration to return usual level. Just like other erectile dysfunction drugs, Tadalafil
works by widening a man’s blood vessels and as a result, when sexually stimulated, the
blood flow to his penis increases, the organ becomes hard, hence an erection.
Although the medication acts similarly to Viagra, Spedra and Levitra its effect lasts longerup to 36 hours. No wonder it is called a weekend pill, simply because a single dose of the
drug can make a man with ED have a normal erection and enjoy sexual intercourse with
his partner for nearly a whole weekend.
When a man takes a 36-hour Tadalafil dose, the drug reduces the PDE5 level in his body
quickly (in about 15 to 45 minutes) and as a result, cGMP returns to normal levels.
Nevertheless, since the medication has a relatively short half-life, its effect disappears
within two days and as a result, the level of PDE5 increases again and the man loses his
penile erection capability again.
On the other hand, when a man is taking daily Tadalafil dose for ED treatment, the drug
helps in keeping cGMP in his body in healthy levels all the time as long as he adheres to
the drug’s prescription religiously. This helps the man to get an erection easily whenever
he’s sexually stimulated. However, the daily dose of low-strength Tadalafil usually takes 4
to 5 days to begin working. So, don’t be in a hurry to become a bed tiger upon taking the
first pill; just let the period lapse and you’ll be just that as long as you take it as prescribed.
Tadalafil– How should I do when I want to take Tadalafil?
Being a prescription-only medication, a man ought to be extra cautious while planning to
take it. Particularly, he ought to do and observe various things before, when and after
Let’s start with the things that one should do before taking the drug.
Do the following before taking Tadalafil:
♦ Visit a doctor or pharmacist for advice on the right Tadalafil dosage for you, among other
♦ In case you are allergic to certain medications, including Tadalafil itself or some of its
ingredients, let the doctor or pharmacist know about it. You can get information about the
ingredients of the drug from the medical expert.
♦ Let your doctor know in case you have taken riociguat or nitrates isosorbide dinitrate
and nitroglycerin in the recent past or still on them. You can confirm from the doctor or
pharmacist if the drugs you are using (if any) have nitrated. You might be advised not to
take Tadalafil if the doctor finds out that you are taking nitrates because they don’t get
along well with Tadalafil.
♦ Remember that Tadalafil comes with a brand name Adcirca or Cialis. Therefore, you
should not take both concurrently, otherwise, you’ll have abused the drug and the
outcome might be undesirable. You should only be treated with any of them at a time.
♦ Are you taking (or planning to take) any other medication, be it prescription or
nonprescription, vitamins or nutritional supplements? If yes, bring it to the attention of the
medical expert. Such information is crucial as it’ll help the doctor or pharmacist to
establish the dosage that will be best for you, considering the other medication or
supplements that you are using or intend to use. Upon having the information, the
specialist may find it necessary to monitor you closely for possible side effects.
♦ Are you using any herbal product, particularly St. John’s wort? If yes, let the specialist
know about it.
♦ In case you are a smoker and at one or several occasions have ever had an erection
that persisted for over four hours, you need to tell your doctor or pharmacist about it.
♦ Tell your doctor if you have vomited, sweated abnormally, had diarrhea, or not been
taking sufficient water and so you suspect that you might be insufficiently hydrated.
♦ Let your doctor know if you have ever suffered from the pulmonary veno-occlusive
disease in your life or any other health condition that’s likely to affect the shape of your
penis. Such conditions include diabetes, high or low blood pressure, heart attack/failure,
blood circulation issues, blood cell issues, irregular heartbeat, chest pain, multiple
myeloma, stomach ulcers, bleeding disorders, a heart disease, a kidney disease, a liver
disease and stroke
♦ If you love alcoholic beverages and you’d like to use them while taking Tadalafil, you
need to discuss with your doctor about it. Upon an assessment of your health, your doctor
will advise you accordingly, whether to avoid the drinks or take them moderately. In the
case of wine or whiskey, you might be advised to take not more than five glasses. This is
because high alcohol intake while one is on the effects of Tadalafil can cause side effects
like low blood pressure, increased heartbeat rate, headache as well as dizziness.
♦ In case you had previously been advised by a health specialist to refrain from having
sexual intercourse due to a medical reason, you should bring it to the attention of your
♦ Tell your doctor if you have ever had chest pain while performing a sexual activity. Your
heart may be strained as a result of your engagement in a sexual activity, particularly if
you are suffering from a heart illness.
♦ Tell your doctor if you’re prostrate or part of it has been removed.
You should not take Tadalafil in case:
♦ You have ever had a vision-impairing condition called Non-arteritic anterior ischemic
optic neuropathy (NAION)
♦ You suffer from a heart illness
♦ You have suffered from stroke or a heart attack, recently, particularly in the last six
♦ You are suffering from low blood pressure
♦ Having uncontrollable hypertension
♦ Allergic to the ingredients of Tadalafil
♦ Bear in mind that the effect of the drug might not be instant. Although 36-hour dose gives
the desired Tadalafil results faster as compared to a daily dose, you are likely to wait for
about 15 to 45 minutes to feel the desired effect of the drug.
♦ Don’t take nitrates for at least 48 hours before the time you are expecting to take
♦ Get Tadalafil from a trusted source. You can count on Phcoker.com for genuine Cialis
products, including Tadalafil.
While taking Tadalafil
♦ Once your doctor has found that you are fit to use Tadalafil and prescribes you the right
dose for the treatment of ED, there are various things that you ought to do while taking the
medications. Here is a list of the dos and the don’ts:
♦ Ensure that you adhere fully to the dosage instruction given by your doctor. Take the
medication precisely the way the specialist advised you. You are supposed to take the
drug at least half an hour prior to the time you have planned to engage in sexual
♦ Swallow the tablet whole with a drink of water. You can take it with or without food. Do
not drink an excessive amount of alcohol while taking the medication, as this increases
your risk of side effects such as dizziness when you stand up.
♦ Avoid drinking grapefruit juice, eating grapefruit or using grapefruit products while you
are taking Tadalafil since grapefruit content can interfere with the effectiveness of the
♦ You should also avoid taking alcohol while using the ED medication. The reaction of the
drug and alcohol can make you experience some side effects.
♦ You should take the drug strictly as per the amount recommended by the doctor; not
more, not less.
♦ Don’t take the medication for a longer period than prescribed.
♦ You can take Tadalafil with or without food
♦ Swallow the Tadalafil tablet whole with a mouthful of water; do not break or split the
♦ You should take Tadalafil before having sex and not more than one time in a day.
♦ You must necessarily be on a dosage schedule of the medication. Therefore, just take it
as prescribed by the medical expert.
♦ In case you’ve missed a dose, don’t take extra Tadalafil to make up. If you missed, just
let it go just like that and continue taking as prescribed.
After taking Tadalafil
♦ Make sure you are sexually stimulated if you want to erect and enjoy sex because the
drug will only be effective if you are stimulated sexually.
♦ In case you are due for a surgery, even the least serious like dental surgery and you
have taken Tadalafil; tell your doctor or surgeon about it prior to the operation.
In case you have recently taken Tadalafil or still on its course and you need emergency
heart problem medical treatment, let your health care provider know about it as well.
Tadalafil reacts to heart medications and so, upon revealing such information to your
health specialist, they’ll be able to establish the safest course of action, considering the
possible effectiveness of Tadalafil in your body. Therefore, your doctor will be interested in
knowing when you last took the medication.
♦ Make sure that you keep the medication at a room temperature, in a cool and dry place;
away from heat and moisture.
Tadalafil– What is it’s side effects?
Although Tadalafil is very effective as an ED treatment, it can cause some undesired
effects. Although a man who has taken the medication is not likely to experience all these
side effects, he should seek medical attention in case he experiences some of them.
▲ The side effects that must require doctor’s attention
king the medication since some of them can be fatal if they are unaddressed on time.
A: The Common side effects
In this case, the common side effects include:
Stuffy nose/ nasal congestion
Loss of hearing capability
Faintness or lightheadedness while getting up quickly from a lying/sitting position
Abnormal exhaustion or weakness
Warmth, redness, or tingly sensation
Swollen lips, tongue or throat
Ringing in your ears
B: Rare side effects
(1) With a severe expression
Although the following Tadalafil side effects are rare, they mostly have a severe
expression if they occur.
Painful or prolonged penis erection
Unusual liver function tests
Blocked or closed eye retina blood vessels
Anal blood discharge
Reduced blood pressure when you stand
Unusually low blood pressure
Eye disease as a result of blood flow issues
Heart throbbing or pounding
Kidney disease and reduced kidney function
Sudden loss of vision
Skin rash and skin sloughing
Stevens – Johnson syndrome
(2) Less Severe expression
The following are also rare side effects of Tadalafil (171596-29-5) but they have a less
severe expression as compared to the previously listed.
Fluid accumulation in the eyelid tissues
A burning sensation in the stomach
Chronic sleep issues
Acquired abnormally colored sight
Abnormal mouth dryness
Short-term memory loss episodes
Too much sweating
Excessive watery eyes
Fluid accumulation in the legs, hands, feet or arms
Too much blood in the eye lining
A spinning or whirling feeling
The above list doesn’t comprise all the side effects of the drugs. Therefore, you are
advised to get comprehensive information about all the possible effects from your doctor.
In case you experience another side effect that is not listed here, you can report it to FDA
▲ The side effects that don’t require doctor’s attention
A Tadalafil side effect must not require medical attention to go away. Some go away by
themselves once your body gets used to the medication. Besides, your health care
provider may advise you on how to prevent or minimize such effects. However, you can
still check with your health specialist if they are persistent or bothering you much. Some
of these side effects are more common than others. Let’s start with the more common:
A: More-common self-healing side effects
Acid or sour stomach
B: Less-common self-healing side effects
These Tadalafil side effects go away on their own without any medical intervention but
they are less-common.
Prickling, “pins and needles”, tingling, crawling and burning sensations
Painful, burning or dry eyes
Dry or a sore throat
Muscle cramps and aches
Neck, arm and/or leg pain
Painful or burning throat
Painful, swollen or reddened eyes, eyelid or eyelid’s inner lining
Reduced sensitivity to touch
Dizziness or unusual drowsiness
Lack of sleep
Impulsive erection of the penis
Puffy or swollen face
Swelling of joints
Upper abdominal or stomach pain
Tadalafil– What are the application forms of Tadalafil?
Tadalafil comes in the form of tablets, liquid or. Whichever form in which you take the
medication, rest assured that it is as effective as the medication in any of the two other
forms. Liquid Tadalafil is similarly effective as or tablet Tadalafil as long as you’ve bought
the medication from a trusted source. Although there might be a difference, it should be
♦ Tadalafil pills or tablets
As earlier mentioned Tadalafil comes as tablets, pills liquid or. Tadalafil tablets or pills
are yellow in colour, coated with a film and are almond-shaped. They are sold in 2.5, 5mg,
10mg and 20mg doses.
The tablets come in packets of 5, 10, 15, 30 and 90 tablets each. You can also get the
medication as a 4, 8, 12, 16 or 28 tablet packet.
Tadalafil tablets for daily use comes in 2.5 mg and 5 mg doses while the 10mg dose is
used only when a man is about to have sex; at least 30 minutes before engaging in a
Considering the effectiveness of the drug in a man and his
tolerability to the medication, the doctor may prescribe the on as-needed dosage to be
increased to 20 mg or reduced to 5 mg. The 5mg when-needed dose is suitable for men
with less-severe ED.
The recommended daily Tadalafil dose is usually 2.5 mg and ought to be taken as at a
specific time every day. However, depending on the efficacy and tolerability, the dosage
may be increased to 5 mg.
▲ Are there Tadalafil counterfeit tablets or pills?
Among the various forms of Tadalafil, the medication in tablet or pill form is the most likely
to be the tablets have been around for the longest time as compared to Tadalafil,
suspensions and gels. The makers of counterfeits know that the drug’s tablets are the
most popular and so, they take advantage of that to supply their fabricated tablet drugs.
Therefore, you need to be extra cautious while buying Tadalafil, especially the tablets.
Preferably, get them from a reputable source, particularly from Phcoker.com, among other
trusted Cialis suppliers and manufacturers. However, that doesn’t mean that you should
not have a keen eye while buying Tadalafil suspensions and gels.
♦ Tadalafil (171596-29-5) liquid
Liquid Tadalafil is milky white in color and just like tablets, should be stored in cool and dry
place, away from heat, moisture as well as direct exposure to light. Men who experience
difficulty swallowing tablets find Tadalafil easier to use while it is liquid form. Besides,
people who are vulnerable to digestive conditions such as dyspepsia prefer liquid Tadalafil
because it is easily digestible and absorbable by the body. Besides, the medication in
liquid form starts working earlier as compared to tablets.
Essentially, it doesn’t matter if you have used liquid Tadalafil or Tadalafil tablets or, as long
as you’ve bought it from a trusted source, you should rest assured of that good erection
you need to feel more masculine. Therefore, you must not spend much of your time
looking for a particular form of the pill (unless you have a swallowing or digestive issue). If
you get the tablets, liquid or, you are good to go.
At the end of the day, it doesn’t matter if you are using liquid Tadalafil or Cialis pills; you
are still more than just likely to achieve that good erection you need. So don’t spend too
much time looking for the better option of the two – they both are good enough to make
you and your partner smile.
The liquid formulations of Tadalafil were released to the market after the tablets. So, they
are less popular as compared to tablets and so, some people might question their
effectiveness but the fact is they are equally effective. All formulations of the medication
use exactly the same active ingredient and so, they are equally reliable. Nevertheless,
ensure that you get liquid Tadalafil from a trusted seller for certainty that you are using
genuine and safe medication.
▲ How to use liquid Tadalafil
Liquid Tadalafil comes in air-tight and easy to open bottles.
You are supposed to shake the bottle first before use to ensure that the solution is
You can use an eyedropper to draw the right dosage of the medication
Put the medication on your tongue and swallow. The drug is tasteless and so, friendly to
people who don’t like tasting medications as well as their unpleasant after back tastes.
A 5ml dose of Tadalafil is enough to help you get an almost-instant reaction. Nevertheless,
remember we said you should take the drug according to your doctor’s instructions.
If you take the drug on an empty stomach, you are likely to get an erection within 15 to 20
minutes of taking it. However, you are going to have the best results of the medication
after about an hour.
Therefore, don’t rush to take another dosage if you don’t see results within 15 to 20
minutes. Just relax and wait for 60 to 90 minutes to see if you’ll have felt the desired effect
of the drug.
If the results are not forthcoming despite waiting for 60 to 90 minutes, consult your
healthcare specialist for guidance on what to do next. Most likely, you’ll be advised to take
an additional 1ml dosage of the medication.
The major differences between liquid Tadalafil and Tadalafil tablets are that the former is
more easily absorbed through the walls the digestive tract and so, it is to a certain extent
softer and gentle on the digestive system. When it comes to the tablets, they must be
broken down to a form in which they can be absorbed by the digestive tract before
absorption and so, their effect takes longer to manifest.
That’s why people who are susceptible to digestive issues like dyspepsia and
gastroesophageal reflux prefer liquid Tadalafil to tablets. The issues are less common
when one takes the liquid formulation and compared to when one has taken the drug in
Tadalafil is the raw material of Tadalafil. The drug is white in colour and is mostly used in
the manufacturing of Tadalafil tablets. You can get genuine Tadalafil from a high-purity
supplier such as Phcoker.com.
Other than making Tadalafil tablets and pills, Tadalafil can also be used to make sexual
candy and sex coffee.
♦ Tadalafil for Sexual candy
Sexual sweets are very prominent among men with sexual issues, especially those with
low sexual drive and those penile erection difficulties as these candies improve their
sexual desire and capabilities. Tadalafil is a common ingredient in such candies. The
candies are sweet and so, encourages one to take the sex enhancement ingredient
♦ Tadalafil for Sex coffee
Ever heard of sex coffee? Well, these are kinds of drinks containing ingredients that can
increase your libido. A certain amount of Cialis can be used to make sex coffee,
depending on the desired strength of the desired sex enhancement effect.
Other than Tadalafil, sex coffee contains other ingredients like coconut milk, maca,
cinnamon, honey and Cacao. Therefore, the drink has a slightly spicy flavor while its
sweetness appeals your taste buds. In as such, you won’t even feel like you are taking a
The amount of Tadalafil in sex coffee is influenced by the desired strength of the effect of
the medication in a man’s body upon taking the drink.
♦ Other forms
Tadalafil also comes as a jelly. Tadalafil jelly is an oral ED medication and you should
allow is to dissolve in your mouth before swallowing it. It is easy to swallow and so,
suitable for people experiencing swallowing difficulties as well as the elderly.
Tadalafil– What about Tadalafil reviews?
The majority of men who have used Tadalafil are thrilled by its results. Let’s sample some
of the feedback we’ve received from our clients about the drug.
Thomson from Europe: “He says that he has been using Tadalafil for the last five months
and he’s happy to have found it. “I am 64 years old and happy because, despite my over
15 years of struggling to enjoy sex with my girlfriends, I can now feel more man since the
time I discovered this drug. I get an erection like I used to do in my early 20s,” he says. He
goes on to advise other men with erection issues to try Tadalafil and he’s certain that they
too will find it helpful.”
Cheng from China: “He says that his newly-wed wife almost left him while on their
honeymoon since he could not satisfy her in bed. He shared the experienced with a friend
who advised him to use Tadalafil. “After taking Tadalafil, we had the best moments of
our honeymoon and the perception that my wife had towards me changed. However, I’m
yet to disclose to her that I use sex enhancement drugs but I’ll let her know with time. I
can’t thank enough whoever came up with this medication,” he says.”
Lam from China: “He says that of all the sex enhancement drugs he has ever used,
Tadalafil is the best. “Its results are instant and last for the longest time as compared to
other brands,” he writes.”
Khatri from India: “Tadalafil is ultra-effective and worth every coin in its price,” he
comments. He adds that although initially, he used to have a fever and facial inflammation
after using it, nowadays he doesn’t experience any side effect upon taking the
Tong from China: “I’m both a consumer and a seller of Tadalafil and from the experience, I
have had with the drug, I can confidently say that it works,” Tong says. “I highly
recommend it to any adult male with erectile dysfunction, “he adds.”
Rodrigues from the U.S: “He says that he bought Tadalafil online, from Phcoker.com to be
precise, and so far so good.”
Zoeng from China: “Tadalafil has helped me big time to regain my self-esteem as a man. I
use it occasionally, especially on weekends when I’m expecting to lay someone and I
have never disappointed me. I would only wish I could get it from my local pharmacy.
Hopeful that the suppliers will do the necessary.”
George: “He says that he and his buddy use Tadalafil and they both like it. He highly
recommends it to other men with penile erection issues.”
Isaac: “Isaac says that he uses Tadalafil and is amazed by its results. “ I wish I knew about
it earlier,” he continues to say.”
Tadalafil– How to buy Tadalafil online?
You don’t have to move up and down looking for a place from which you can buy Tadalafil.
You can simply buy the medication from Phcoker.com at the comfort of your PC or
Here are the steps of the online purchase:
♦ Go to Phcoker.com website
♦ Search “Tadalafil”
♦ Fill and submit the application form for the purchase
♦ You might be asked to fill in a short medical questionnaire; fill it in and submit. Our
specialist will review and possibly approve your order.
♦ Once your order is approved, you’ll pay for the product and then wait for Phcoker.com to
deliver it to you.
（1）Tadalafil price in the market
Tadalafil is sold at different prices by different sellers. Here is a sample price range of
Tadalafil Canada as at the time of writing this article (November 2018).
Number of tablets per packet
Weight per tablet
Market Price range
2. 5 mg
2. 5 mg
2. 5 mg
2. 5 mg
2. 5 mg
Hopefully, the table gives you a glimpse of Tadalafil cost.
（2）Tadalafil supplier/manufacturer from different countries
Xuchang Shangke Chemical Co., Ltd, also known as Phcoker, is a China-based high-tech
enterprise that specializes in the manufacturing of active pharmaceutical intermediates
and products which include Tadalafil. The company deploys top-creams in the
pharmaceutical industry as well as state-of-the-art equipment besides using top-class
laboratories for accurate production quality control. Phcoker.com is a go-to shop for
customers from China, North America, Europe and India who need genuine Tadalafil. It
is where you can get Tadalafil best price.
There are other companies that supply Tadalafil to various parts of the globe. Here is a
table indicating the other active manufacturers
they are based:
and suppliers and the countries in which
Tadalafil (171596-29-5) —Summary
Men, especially those who’ve hit 60 years are susceptible to ED. Luckily, following the
release of Tadalafil; every man now can enjoy having good sex irrespective of his age,
thanks to the effect of the medication. Nevertheless, you should seek advice from a
healthcare specialist if you want to use this medication to avoid some possible side
Even having adhered to doctor’s advice, a man who has used Tadalafil can experience
one or several side effects, some of which require professional medical attention while
others can just disappear on their own with time.
Tadalafil comes as tablets, pills, liquid,, candies and coffee as well as in a jelly form.
Tadalafil tablets, pills and liquid are equally effective since they have the same active
ingredients. When it comes to coffee and candies, the effectiveness of the drug is
dependent on the quantity of the medication used as an ingredient in the products.
If you want to be sure that the Tadalafil that you are using is genuine, purchase it from a
trusted Tadalafil supplier or Tadalafil manufacturer like Phcoker.com. Tadalafil is your
go-to drug for you ED treatment need as a man.
1.National Centre For Biotechnology Information, US. National Library Of Medicine,
Tadalafil, Pubchem Sections 1-10.
2.Evelyn C. Cortez, CIALIS (Tadalafil): Uses, Dosage, Side Effects Information and Where
to Buy Generic Cialis (Tadalafil), Viagra (Sildenafil), and Other Best Drugs Cheap and
Safely Online, Published, 13 Dec 2017, page 5-3
3.James Lee Anderson, Cialis, Tadalafil: Treats Erectile Dysfunction, Symptoms of Benign
Prostatic Hyperplasia, and Pulmonary Arterial Hypertension, CreateSpace Independent
Publishing Platform, 26 Mar 2015, page 5-47.
Hot topic discussion：
Is Tadalafil Safe?
an I drink with Cialis?
How can I improve my erectile
How to improve tadalafil effects?
What is the best pill for
How long can you take tadalafil
For more information: https://www.phcoker.com