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10:50-11:05
11:05-11:10

Bispecific T-cell therapy (BiTEs)
Discussion

Max Topp (Wurzburg)

11:10-11:25

Hagop Kantarjian (Houston)

11:25-11:30

Poor penetration of existing effective chemoimmunotherapy for the treatment of older newly diagnosed
and refractory-relapsed (R-R) ALL
Discussion

11:30-11:45
11:45-11:50

Chimeric antigen receptor (CAR) gene-modified T cells
Discussion

Claudia Rossig (Munster)

11:50-12:05
12:05-12:10

Novel adoptive cell therapies
Discussion

Rupert Handgretinger (Tubingen)

KEYNOTE LECTURE
Chair: Hervi Dombret (Paris)
12:10-12:25
12:25-12:30

BiTEs, ADC, CAR-T, allogeneic HSCT, what’s first?
Discussion

Dieter Hoelzer (Frankfurt)

12:30-12:37

Richard Lock (Sydney)

12:37-12:40

Novel agents for the treatment o f high-risk Acute
Lymphoblastic Leukaemia in children
Discussion

12:40-13:00

Panel discussion

13:00-14:00

Lunch

ROUND TABLE 2: ADULT VS PAEDIATRIC OPINIONS
Should \1RD overcome baseline factors in risk assessment?
Chair: Andrl Baruchel (Paris)
14:00-14:15

Adult opinion

Renato Bassan (Venice)

14:15-14:30

Integrating, balancing and disregarding risk factors
in paediatric leukaemia

Anthony Moorman (Newcastle)

14:30-14:45

Discussion

14:45-15:15

Coffee Break

SESSION V - ISSUES IN ALLOGENEIC HSCT
Chair: Jan Cornelissen (Rotterdam)
Mark Litzow (Rochester)

15:30-15:35

Indications for allogeneic HSCT in adult Acute
Lymphoblastic Leukemia
Discussion

15:35-15:50
15:50-15:55

Post allograft relapse of ALL
Discussion

David Marks (Bristol)

15:55-16:10
16:10-16:15

New haplo-idcntical HSCT modalities
Discussion

Franco Locatclli (Rome)

15:15-15:30

4

16:22-16:25

Minimal residual disease is the most important risk
factor in pediatric T-Cell Acute Lymphoblastic Leukemia:
a collaborative study o f the biological committee o f
the leukemia group o f the Spanish hematology and
oncology pediatric society
Discussion

16:25-16:45

Panel discussion

17:00-18:00

Simultaneous Meet the Expert sessions:

16:15-16:22

- Practical issues with blinatumomab and inozutumab ozogamicin
- Post-transplant management of Ph-positive ALL
- Reduced toxicity conditioning for older ALL HSCT

Mireia Camos (Barcelona)

Hagop Kantarjian (Houston)
Oliver Ottmann (Cardiff)
Jan Comclisscn (Rotterdam)

Sunday, May 19,2019
SESSION VI - PHILADELPHIA CHROMOSOME-POSITIVE ALL
Chair: Adele Fielding (London)
08:00-08:15
08:15-08:20

Risk factors in Ph+ ALL
Discussion

Sabina Chiaretti (Rome)

08:20-08:35
08:35-08:40

Optimal use of TKIs to treat Ph+ ALL?
Discussion

Hervd Dombrct (Paris)

08:40-08:55
08:55-09:00

Synopsis of presentation : «Are next generation TKI better
Oliver Ottmann (Cardiff)
for Philadelphia chromosome positive (Ph+) acute lymphoblastic
leukemia (ALL)?»
Discussion

09:00-09:15
09:15-09:20

Minimal residual disease monitoring in Ph+ ALL
Discussion

Jan Zuna (Prague)

09:20-09:27

Ilaria Tanasi (Verona)

09:27-09:30

Prospective diagnosis o f Ph-like ALL enables efficient TKI
therapy in patients with ABL-class alterations
Discussion

09:30-09:50

Panel discussion

09:50-10:20

Coffee Break

ROUND TABLE 3: DIFFICULT TO TREAT ALL SUBGROUPS
Chair: Mark Litzow (Rochester)
10:20-10:35

Diagnosis and treatment of BCR-ABL1-like/philadelphia-like
ALL; hurdles and opportunities

Monique den Boer (Utrecht)

10:35-10:50

The changing pattern of relapse in the immunotherapy era

Andre Baruchel (Paris)

10:50-11:05

Discussion

5

SESSION VII - T-CELL ALL/LL
Chair: David Marks (Bristol)
Jordy Van Der Zwet (Utrecht)

11:20-11:25

IL7 signaling mutations induce steroid resistance in T-cell
acute lymphoblastic leukemia
Discussion

11:25-11:40
11:40-11:45

Nclarabinc in T-ALL/LL
Discussion

Clare Rowntree (Cardiff)

11:45-12:00
12:00:12:05

Novel therapies for T-ALL/LL
Discussion

Nicolas Boissel (Paris)

12:05-12:20
12:20-12:25

Place of allogeneic HSCT in T-ALL/LL
Discussion

Jan Comelisscn (Rotterdam)

12:25-12:32

Frederik van Delft
(Newcastle upon Tyne)

12:32-12:35

An in vivo genome wide CR1SPR screen to identify
mechanisms underlying drug resistance to induction therapy
in T-ALL
Discussion

12:35-12:55

Panel discussion

12:55-13:00

Closing Remarks

11:05-11:20

Mark Litzow (Rochester)

MEETING CLOSURE

6


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