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Trump Recommends Hydroxychloroquine & Azithromycin For Covid 19, Does It Really Work .pdf


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Hunan Huateng Pharmaceutical Co. Ltd.

https://en.huatengsci.com

Trump Recommends Hydroxychloroquine
& Azithromycin For Covid-19, Does It
Really Work?
With the rapid spread of the epidemic, novel coronavirus disease 2019
(COVID-19) has also attracted global attention.

The number of confirmed cases in the United States doubled within 48 hours,
becoming the country with the second largest number of confirmed cases
outside China, behind Italy. Faced with an increasingly severe epidemic,
Trump's attitude towards COVID-19 has also undergone a "subtle" change.
On Saturday (March 21), Trump lobbied for hydroxychloroquine and
azithromycin, saying that hydroxychloroquine combined with azithromycin does
have the opportunity to play a subversive role in the history of drugs to inhibit
COVID-19. The tweet said: "Hopefully they will BOTH (H works better with A,
International Journal of Antimicrobial Agents) be put in use IMMEDIATELY.
PEOPLE ARE DYING, MOVE FAST, and GOD BLESS EVERYONE!"

Hunan Huateng Pharmaceutical Co. Ltd.

https://en.huatengsci.com

Research Confirms: Azithromycin + Hydroxychloroquine
Negative Rate Is 100%
Trump's recommendation was not groundless. On the same day, he also
retweeted an effective tweet about hydroxychloroquine combined with
azithromycin for the treatment of novel coronavirus.

The research paper entitled "Hydroxychloroquine and azithromycin as a

Hunan Huateng Pharmaceutical Co. Ltd.

https://en.huatengsci.com

treatment of COVID-19: results of an open-label non-randomized clinical trial"
published online by the Didier Raoulta team in the International Journal of
Antimicrobial Agents showed that the combination of hydroxychloroquine and
azithromycin has a significant effect on COVID-19. The patients in the study
completely eliminated the virus on the fifth day of treatment.
Looking specifically at this study, a total of 36 COVID-19 patients (6
asymptomatic, 22 with upper respiratory infection symptoms, and 8 with lower
respiratory infection symptoms) participated in this clinical trial, of which 20
received receive 600mg of hydroxychloroquine daily and their viral load in
nasopharyngeal swabs was tested daily in a hospital setting. Depending on their
clinical presentation, azithromycin was added to the treatment. Another 16
were the control group.

As shown in the figure, on the 6th day, the nasopharyngeal swab virus negative
rate was 100% in patients receiving hydroxychloroquine and azithromycin,
while the negative rate was only 57.1% in patients receiving
hydroxychloroquine monotherapy. The negative rate was even as low as 12.5%
(p <0.0001). And compared with asymptomatic patients, the drug efficacy of
patients with symptoms is more significant.
It can be seen that hydroxychloroquine is indeed effective in treating patients
with COVID-19, and hydroxychloroquine combined with azithromycin is more
effective. However, many experts believe that the sample size of this
experiment is too small and the lack of randomized trials remains to be
considered.

Hunan Huateng Pharmaceutical Co. Ltd.

https://en.huatengsci.com

What You Should Know About These Two Drugs
Hydroxychloroquine is an oral drug prescribed for treating malaria and certain
inflammatory conditions, while Azithromycin is used to treat certain bacterial
infections, such as bronchitis; pneumonia.
As per the Centers for Disease Control and Prevention, hydroxychloroquine and
azithromycin are associated with QT prolongation, which is a measure to
delayed ventricular repolarisation. In this process, the heart muscle takes
longer than normal to recharge between beats. So, it is advised to use the drugs
cautiously on patients with chronic medical conditions like renal failure and
hepatic disease.

The Bottom Line
This clinical trial was approved by the French National Agency for Drug Safety
(ANSM) and the French Ethics Committee for reviewing and approved.
As per the CDC, hydroxychloroquine is currently under investigation in clinical
trials for the pre-exposure or post-exposure treatment of patients with mild,
moderate and severe COVID-19.
The trail is indeed promising, but still a lot more research and approval are
needed before using the shot of drugs on masses.
Other Therapeutic Options for COVID-19:
Nature Reviews: Novel Coronavirus (2019-nCoV) Treatment Options
Favipiravir/Avigan Shows Good Clinical Efficacy Against COVID-19
Huateng Pharmaceutical has completed the kilogram-level synthesis of multiple
anti-COVID19 infection candidate drugs, and preparation work is ongoing.
eg. Favipiravir intermediates, Remdesivir intermediates.


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