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Activated DBCO PEG for Copper Free Click Chemistry .pdf


Original filename: Activated DBCO PEG for Copper Free Click Chemistry.pdf
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Biochempeg

https://www.biochempeg.com

Activated DBCO PEG for Copper Free Click
Chemistry
Click Chemistry has found a wide range of applications in bioconjugation in the
pharmaceutical and biotechnology industries. It is a term introduced by KB
Sharpless in 2001 to describe a high yield, a wide range reaction that only
produces by-products. These by-products can be separated without
chromatography, are stereospecific, easy to perform, and can be conducted in
easily removable or benign solvents.
Biochempeg provides many PEG Azide and PEG Alkyne derivatives for the
conventional click chemistry reaction with copper (I) (CuAAC), but due to the
cytotoxicity of the catalyst, the application of this reaction in biomedical
systems is limited.
The novel copper-free click chemistry is based on the reaction of a
cyclooctyne (DBCO) moiety with an azide-labeled reaction partner (called
strain-promoted alkyne azide cycloaddition (SPAAC)). This new "click
chemistry" is very fast at room temperature and does not require cytotoxic Cu
(I) catalysts. Cyclooctyne has high thermal stability, very narrow and specific
reactivity with azide, resulting in almost quantitative yields of stable triazoles.
This unique covalent bond is generated when DBCO incorporated into one
biomolecule reacts with the azide linker incorporated into the second
biomolecule.

Biochempeg

https://www.biochempeg.com

Features and Advantages Of Copper-Free Click Chemistry
• Biocompatibility – no cytotoxic copper catalyst is required – good in vivo
application.
• Mild conditions –conjugation in an aqueous buffer medium and at low
temperatures
• Stability – DBCO and azide moieties are stable for a long time
• Efficiency – stable triazole formation in quantitative yield
• Specificity and biological orthogonality – Azides only react with DBCO in the
presence of -NH2, -SH, -COOH and other protein functionalities
However, most cyclooctyne reagents do not have good water solubility,
which limits their application in biomedicine. Compared with cyclooctyne,
Biochempeg's DBCO PEG derivatives have good water solubility, and have
better biocompatibility and no cytotoxicity than traditional click reagents.
Biochempeg has enhanced its ability to provide high-quality PEG DBCO
products in large kilograms and above at very affordable prices.
The following are a few examples of PEG DBCO products produced by
Biochempeg. PEG and monodisperse PEG DBCO derivatives with different
branches, molecular weight and functionality can be obtained by custom
synthesis.

Methoxy PEG DBCO Products (mPEG-DBCO)
Name

M.W.

Unit

Price (USD)

mPEG-DBCO-1K

1K

100mg

$195.00

mPEG-DBCO-1K

1K

1g

$995.00

mPEG-DBCO-2K

2K

100mg

$195.00

Biochempeg

https://www.biochempeg.com

mPEG-DBCO-2K

2K

1g

$995.00

mPEG-DBCO-5K

5K

100mg

$195.00

mPEG-DBCO-5K

5K

1g

$995.00

mPEG-DBCO-10K

10K

100mg

$195.00

mPEG-DBCO-10K

10K

1g

$995.00

mPEG-DBCO-20K

20K

100mg

$195.00

mPEG-DBCO-20K

20K

1g

$995.00

Homobifunctional PEG DBCO Products (DBCO-PEG-DBCO)
Name

M.W.

Stock

Price (USD)

DBCO-PEG-DBCO-2K

2K

In Stock

Inquiry

Multi-arm PEG DBCO Products (4-ArmPEG-DBCO, 8-ArmPEG-DBCO)
Name

M.W.

Stock

Price (USD)

4-ArmPEG-DBCO-10K

10K

In Stock

Inquiry

4-ArmPEG-DBCO-20K

20K

In Stock

Inquiry

8-ArmPEG-DBCO-20K

20K

In Stock

Inquiry

Heterobifunctional PEG DBCO Products (PEG-DBCO)
Name

M.W.

Price (USD)

NH2-PEG-DBCO

800, 1K, 2K, 3.4K, 5K, 10K Inquiry

DBCO-PEG-OH

500, 2K

DBCO-PEG-SH

400, 600, 1K, 2K, 3.4K, 5K Inquiry

DBCO-PEG-COOH

1K, 2K, 3.4K, 5K

Inquiry

Inquiry

Biochempeg

https://www.biochempeg.com

DBCO-PEG-Silane

1K, 2K, 3.4K

DBCO-PEG-Mal

1K, 2K, 3.4K, 5K, 10K, 20KInquiry

DBCO-PEG-NHS

DBCO-PEG-Biotin

Inquiry

200, 400, 500, 600, 800,
1K, 2K, 3.4K, 5K, 6K, 8K, Inquiry
10K, 20K
200, 400, 500, 600, 800,
1K, 2K, 3.4K, 5K, 6K, 8K, Inquiry
10K, 20K

DBCO-PEG-FA

1K, 2K, 5K

Inquiry

DBCO-PEG-SVA

1K

Inquiry

And More...


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