Antibody Drug Conjugates Against Tumor Stroma What Can We Do .pdf
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Antibody Drug Conjugates Against Tumor
Stroma: What Can We Do?
Antibody-drug Conjugates or ADCs are highly targeted biopharmaceutical
drugs that combine monoclonal antibodies specific to surface antigens present
on particular tumor cells with highly potent anti-cancer agents linked via a
chemical linker. The linker plays a key role in determining the
pharmacokinetic properties, therapeutic index, selectivity and the overall
success of the ADC.
PEG-linkers are particularly attractive as a linker for conjugation. Water
solubility, lack of toxicity; low immunogenicity and well defined chain lengths
and molecular weights are specific characteristics of PEG moieties relevant to
Biochempeg develops a broad range of PEG linkers and provides custom
linker synthesis for clients worldwide.