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Increasing RyR1-neuro toxicity equivalents with increasing homologue number and Aroclor chlorination likely reﬂect indirect molecular controls on toxicity, since congeners with multiple ortho substituents—the primary structural feature controlling a lack of coplanarity and resulting neurotoxicity—are more likely to be found in higher homologues.
Rather than simply determining the total quantities of broad contaminant classes (e.g., total pesticides, Aroclor mixtures, etc.), levels of individual compounds are necessary to properly assess the extent of environmental pollution.