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Because BAG proteins can regulate positively and negatively the function of Hsp70/Hsc70, we also checked whether Stv expression was related to Hsp70 and Hsc70.
Based on qPCR data, we associated these survival patterns to variations in the expression of the hsp70 gene, a generic biomarker of stress.
The major families include Hsp100, Hsp90, Hsp70, Hsp60, Hsp40, and the small Hsps (sHsps) (sizes below 30 kDa) [2,3].
A reduction in the expression of the protein Hsp70 was found to accompany the age-related decline in THE JOURNAL OF EXPERIMENTAL BIOLOGY 254 The Journal of Experimental Biology 216 (2) heat tolerance in D.
Sørensen and Loeschcke, 2007), with the exception of Hsp70 (Michaud and Denlinger, 2004;
Acclimation also inﬂuenced expression of several genes (Hsp23, Hsp70, Hsp40, Hsp68, Starvin and Frost) during recovery from cold stress but effects depended on the nature of the acclimation treatment.
A proteomic study in parasitic wasps, Aphidius colemani, found that HSP70 and HSP90 accumulate under FTR (Colinet et al., 2007a).
These authors observed small but significant larval heat-shock protein 70 (HSP70) up-regulation correlated with enhanced heat stress tolerance of adults raised under high larval density.
Here, we report up-regulation of numerous putative hsps, including members of the small heat shock protein (three members), hsp40 (two members), hsp70 (eight members), and hsp90 (one member) families (Dataset S1).
The reduced mortality under FTR was associated with up-regulation of several proteins playing key roles in energy metabolism (glycolysis, TCA cycle, synthesis and conversion of ATP), protein chaperoning (Hsp70/Hsp90), and protein degradation (proteasome).
Regulation of signaling protein function and trafﬁcking by the hsp90/hsp70-based chaperone machinery.