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Glands Round, tubular lined by psuedostratified columnar epithelium Stroma Very cellular (compact, dense) Gland Evenly distributed Distribution - If uneven, there may be a pathology Mitotic figures are numerous, and there is no evidence of mucus secretion or vacuolation.
Often neuroendocrine cells show minimal pleomorphism but they can evolve in anaplasia andrapid mitotic activity leading to intratumoral areas of necrosis.
as we know, nerve cells experience mitotic division only during prenatal period.
Canonical chemotherapeutic treatments are anti-mitotic and function by inhibiting tumor cell replication.