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Treatment with STI1 prevented A␤O-induced synaptic loss and neuronal death in mouse cultured neurons and long-term potentiation inhibition in mouse hippocampal slices.
Glutamate excitotoxicity is suggested as a possible cause of neuronal degeneration in schizophrenic patients with negative features.
Ultrastructural analysis experiments have found phagocytic activated microglia with neuronal elements inside in schizophrenic brains14.
sAPP-α enhances neuronal development and is critical in neuroregenerative processes;
AFM and optical microscopy are used to illustrate the differences pertaining to PLL, PLO and collagen coated glass surfaces used as culture substrates for neuronal cell culture.
PC12 cells Neurite outgrowth Surface energy Surface chemistry Self-assembled monolayers Atomic force microscopy a b s t r a c t PC12 cells are a useful model to study neuronal differentiation, as they can undergo terminal differentiation, typically when treated with nerve growth factor (NGF).
www.elsevier.com/locate/biomaterials Neuronal adhesion and differentiation driven by nanoscale surface free-energy gradients Guillaume Lamour a, b, Ali Eftekhari-Bafrooei b, Eric Borguet b, Sylvie Soue`s c, Ahmed Hamraoui a, d, * a Neuro-Physique Cellulaire, Universite´ Paris Descartes, UFR Biome´dicale, 45 Rue des Saints-Pe`res, 75006 Paris, France Department of Chemistry, Temple University, Philadelphia, Pennsylvania, PA 19122, USA c Re´gulation de la Transcription et Maladies Ge´ne´tiques, CNRS UPR2228, Universite´ Paris Descartes, UFR Biome´dicale, 45 Rue des Saints-Pe`res, 75006 Paris, France d Service de Physique et Chimie des Surfaces et Interfaces, CEA Saclay, 91191 Gif-sur-Yvette, France b a r t i c l e i n f o a b s t r a c t Article history:
The purine nucleotide adenosine is a ubiquitous modulator of neuronal function in the central and peripheral nervous systems.
Substrate factors such as surface energy distribution can affect cell functions, such as neuronal differentiation of PC12 cells.
1 Effects of Coenzyme Q10 in Early Parkinson Disease: