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by PCBs is enhanced by congeners with ortho/para or ortho/meta substitution.[2−4,11−27] Since the mid-1990s, Pessah and coworkers have progressively developed a primarily qualitative structure-activity based understanding of how PCBs alter calcium regulation and associated neuronal signalling by ryanodine receptor (RyR) mediated mechanisms.[28−34] RyR receptors are proteins that act as high conductance calcium channels, and which release Ca2+ stored within sarcoplasmic/endoplasmic reticulum membranes. The following three genetic isoforms of RyR receptors exist:
Final Brochure 98%
Environmental Chemicals and Autism Risk— Isaac Pessah, PhD, Professor of Toxicology, The University of California, Davis School of Medicine >