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Because of their pervasiveness in eukaryotic genomes and their unique properties, understanding the role that ID (intrinsically disordered) regions in proteins play in the interactome is essential for gaining a better understanding of the network.
The reduced mortality under FTR was associated with up-regulation of several proteins playing key roles in energy metabolism (glycolysis, TCA cycle, synthesis and conversion of ATP), protein chaperoning (Hsp70/Hsp90), and protein degradation (proteasome).
Reversible phosphorylation is a widespread post-translational modification that can rapidly alter proteins function(s).
Received 1 February 2010 Received in revised form 11 March 2010 Accepted 15 March 2010 In Drosophila melanogaster, the sole member of the Bcl-2-associated anthanogene (BAG)-family proteins, called Starvin (Stv), has only been recently described.
I pioneered the method of cDNA cloning of mRNA copies, used for production of recombinant proteins for research (e.g.
We hypothesized that the marked organismal responses to acclimation could be detected at the proteomic level assuming that changes in the abundance of speciﬁc proteins are linked to the physiological changes underlying the phenotypic response.
Biophysical Journal Volume 103 December 2012 2361–2368 2361 The Molecular Mechanism Underlying Mechanical Anisotropy of the Protein GB1 Yongnan Devin Li,† Guillaume Lamour,†‡ Jo¨rg Gsponer,‡ Peng Zheng,† and Hongbin Li†* † Department of Chemistry and ‡Center for High-Throughput Biology, University of British Columbia, Vancouver, British Columbia, Canada ABSTRACT Mechanical responses of elastic proteins are crucial for their biological function and nanotechnological use.
Using 2D-DIGE, we found that only a few proteins signiﬁcantly changed in abundance, and of these, we identiﬁed a set of four proteins of particular interest.
DESIGN PROJECTS GROW YOUR OWN PROTEINS Design project 1/5 Grow Your Own Proteins “Grow Your Own Proteins” is my answer to the Electrolux design lab contest (2014).
A large set of proteins were modulated during diapause and these were involved in various functions such as remodeling of cytoskeleton and cuticle, stress tolerance, protein turnover, lipid metabolism and various metabolic enzymes.
o Transmembrane Protein § A protein that spans across the membrane lipid bilayer, at least once o Viral Receptor § A cell surface molecule that is bound by a virus to mediate its entry into host cells o Tropism § The phenomenon that viruses are capable of infecting certain cell types but not others o Endocytosis § Cellular uptake of materials from extracellular space, using membrane-bound vesicles called endosomes o Highly pathogenic avian influenza (HPAI) § Avian flu virus that has crossed over from waterfowl to domestic birds and causes high rate of death in the latter population • Objectives o Understand the general steps of a virus life cycle § Entry, this includes receptor-binding all the way to membrane penetration Replication of viral genomes, which requires the expression of replication enzymes § Viral assembly and exit, which requires the expression of structural proteins o Understand the structure of biological membranes § Lipid bilayer with embedded Transmembrane proteins § A barrier that viruses must cross to deliver its genome into the cells o Understand the importance of studying viral receptors § Elucidation of viral tropism § Help predicting viral pathogenesis § § Reveal drug targets for therapy o Know the 4 possible routes of viral entry, following receptorbinding § Pore formation at the cell surface (neutral pH) § Membrane fusion at the cell surface (neutral pH) § Pore formation in the endosomes (acidic pH) § Membrane fusion in the endosomes (acidic pH) Ch 3 Genome Replication • Definitions: