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Cannabinoids as medicine 100%

Cannabinoid receptors (CB1 and CB2) are activated by cannabinoid agonists, which augment endocannabinoid signalling.

https://www.pdf-archive.com/2016/09/14/cannabinoids-as-medicine/

14/09/2016 www.pdf-archive.com

Alexander2014 97%

G protein–coupled receptors catalyze GDP release on cognate G proteins through a mechanism that is not fully elucidated;

https://www.pdf-archive.com/2016/06/02/alexander2014-1/

02/06/2016 www.pdf-archive.com

ABOUT NMDARE 97%

It is thought that antibodies are initially formed against NMDA receptors found within tumour, and then attack similar-looking receptors in the brain, thinking that it is another tumour.

https://www.pdf-archive.com/2017/01/09/about-nmdare/

09/01/2017 www.pdf-archive.com

Review of Basic Neuroscience 97%

 Peripheral serotonergic receptors in the intestine regulate intestinal secretions and motility (5HT 3,4 &7).

https://www.pdf-archive.com/2018/01/19/review-of-basic-neuroscience/

19/01/2018 www.pdf-archive.com

Grannys%20List%20A-H 97%

(2005) http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1681626&tool=pmcentrez ACEA/ ARACHIDONYL-2'-CHLOROETHYLAMIDE - synthetic, CB1 agonist The cannabinoids R(-)-7-hydroxy-delta-6-tetra-hydrocannabinol-dimethylheptyl (HU210), 2-O-arachidonoylglycerylether (HU-310) and arachidonyl-2-chloroethylamide (ACEA) increase isoflurane provoked sleep duration by activation of cannabinoids 1 (CB1)-receptors in mice.

https://www.pdf-archive.com/2013/06/13/grannys-20list-20a-h/

13/06/2013 www.pdf-archive.com

PG2-Autonomics-ANSWERS-F16-1 97%

Nitric oxide would cause vasodilation and a reflex increase in HR (mediated by activation of cardiac β1 receptors).

https://www.pdf-archive.com/2017/08/29/pg2-autonomics-answers-f16-1/

29/08/2017 www.pdf-archive.com

JDIT-2014-0712-002 96%

This PET study was conducted to investigate the receptor occupancy of 11CSCH442416 in the human brain and to determine plasma concentrations and dose of preladenant which result in inhibition of 11C-SCH442416 binding to adenosine 2A receptors.

https://www.pdf-archive.com/2017/05/30/jdit-2014-0712-002/

30/05/2017 www.pdf-archive.com

FitnessEndocrinologyMetabolicProcessesRegulation1.2.1 96%

Endocrinology and Metabolic Processes Regulation  Athletic Success via Biochemical Supplementation  ● ● ● Author: Eva  Date: 2016­01­30  Rev: 1.2.1    Note​ : This is a work in progress for my own purposes. It is currently evolving. Resources are listed in  brackets with source links at the end of the document. If otherwise not noted/bracketed, the writing is  from the author’s own contextual knowledge. Conclusions are bolded where deemed relevant to a  topic.    A Quick Intro to Endocrinology and Metabolism  Prior to getting into any concepts or useful conclusions there are several background terms  and elements that the reader should be familiar with. We’ll start with fundamentals and touch  on several core elements before introducing the cyclical elements of endocrinology and the  metabolic cycle. These terms, concepts, and cycles are essential to understanding how one’s  diet and hormonal balances are controlled by diet, which in turn defines how our physical  form is capable of performance, growth, decline, and overall change.    Fundamental Terms  The following terms will come up occasionally throughout this document and, as such, one  would benefit from knowing the context around them prior to continuing.    Endogenous  Originating from within an organism, not attributable to any external or environmental factor.  eg: biologically produced estrogen created by the ovaries.    Exogenous  Originating from outside an organism, caused by an agent or organism outside the body. eg:  hormone replacement medication taken by injection.    MacroNutrients  The combined requirements of base nutrition required to sustain healthy human existence.  There are three primary macronutrients: protein, fat, and carbohydrate. [1] Macronutrients  are defined as a class of chemical compounds which humans consume in the largest  quantities (must be above a threshold amount) and which provide humans with the bulk of  energy. [31]    CNS, The Central Nervous System  The central nervous system is composed of the brain and spinal cord. Your brain and spinal  cord serve as the main "processing center" for the entire nervous system, and control all the  workings of your body.    PSN, The Peripheral Nervous System  The peripheral nervous system consists of the nerves that branch out from the brain and  spinal cord. These nerves form the communication network between the CNS and the body  parts. The peripheral nervous system is further subdivided into the somatic nervous system  and the autonomic nervous system. The somatic nervous system consists of nerves that go  to the skin and muscles and is involved in conscious activities. The autonomic nervous  system consists of nerves that connect the CNS to the visceral organs such as the heart,  stomach, and intestines. It mediates unconscious activities.    Endocrinology  A branch of biology and medicine dealing with the endocrine system, its diseases, and its  specific secretions known as hormones. It is also concerned with the integration of  developmental events proliferation, growth, and differentiation, and the psychological or  behavioral activities of metabolism, growth and development, tissue function, sleep,  digestion, respiration, excretion, mood, stress, lactation, movement, reproduction, and  sensory perception caused by hormones.    Metabolism  The set of life­sustaining chemical transformations within the cells of living organisms. These  enzyme­catalyzed reactions allow organisms to grow and reproduce, maintain their  structures, and respond to their environments.    Pharmacokinetics  Sometimes described as what the body does to a drug, refers to the movement of drug into,  through, and out of the body ­ the time course of its absorption, bioavailability, tissue  distribution, metabolism, and excretion. [52]  Endocrinology: Communication and Message Relays  The endocrine system is a collection of glands that secrete hormones directly into the  circulatory system to be carried towards distant target organs. The major endocrine glands  include the pineal gland, pituitary gland, pancreas, ovaries, testes, thyroid, parathyroid,  hypothalamus, gastrointestinal tract, and adrenal glands.    The Role of Hormones in Endocrinology  Hormones are the body’s signaling molecules that are used to communicate between organs  and tissues. They regulate physiological and behavioral activities, such as digestion,  metabolism, respiration, tissue function, sensory perception, sleep, excretion, lactation,  stress, growth and development, movement, reproduction, and mood. The particulars of each  hormone are covered in the section titled “Neurotransmitters, Hormones, and Histamines”.    An Overview of Hormonal Biosynthesis        Receptors  In biochemistry and pharmacology, a receptor is a protein molecule usually found embedded within the plasma membrane surface of a cell that receives chemical signals from outside the cell.

https://www.pdf-archive.com/2016/02/02/fitnessendocrinologymetabolicprocessesregulation1-2-1/

02/02/2016 www.pdf-archive.com

CV 96%

Gonadotropin-induced expression of receptors for growth hormone releasing factor in cultured granulosa cells.

https://www.pdf-archive.com/2017/09/14/cv/

14/09/2017 www.pdf-archive.com

JDIT-2014-0620-001 96%

www.openmedscience.com Research Article Quantitative in vivo Imaging of Adenosine A2A Receptors in the Human Brain Using 11C-SCH442416 PET:

https://www.pdf-archive.com/2017/05/30/jdit-2014-0620-001/

30/05/2017 www.pdf-archive.com

Sayed Amin Dadsepah - HIV Comprehensive Review 96%

These tools include the CD4 receptor and chemokine co-receptors.

https://www.pdf-archive.com/2016/05/16/sayed-amin-dadsepah-hiv-comprehensive-review/

16/05/2016 www.pdf-archive.com

Grannys%20List%20I-Z 95%

(news – 2011) http://hailmaryjane.com/a-legit-cannabis-pill-you-dont-say/ IMMUNE SYSTEM Presence and functional regulation of cannabinoid receptors in immune cells.

https://www.pdf-archive.com/2013/06/13/grannys-20list-20i-z/

13/06/2013 www.pdf-archive.com

JDIT-2014-1007-004 93%

Two-thirds of breast carcinomas express estrogen receptors (ERs).

https://www.pdf-archive.com/2017/05/30/jdit-2014-1007-004/

30/05/2017 www.pdf-archive.com

0002PRN 92%

Tianeptine, an atypical antidepressant patented and developed by Servier, enhances the synaptic reuptake of serotonin, without affecting norepinephrine and dopamine uptake, while it lacks affinity for neurotransmitter receptors.

https://www.pdf-archive.com/2013/12/30/0002prn/

30/12/2013 www.pdf-archive.com

art 10.1007 s11481-013-9485-1 92%

1970), but the basis for this activity was not understood until the cannabinoid receptors were cloned.

https://www.pdf-archive.com/2015/01/23/art-10-1007-s11481-013-9485-1/

23/01/2015 www.pdf-archive.com

Guineafowls 92%

(2003) Association of feather colour with constitutively active melanocortin 1 receptors in chicken.

https://www.pdf-archive.com/2016/02/23/guineafowls/

23/02/2016 www.pdf-archive.com

The-Mind-Bending-Quest-for-Cognitive-Enhancers 91%

No definite success has been found with AMPA modulators, glycine site NMDA receptors agonists, or glycine reuptake inhibitors.

https://www.pdf-archive.com/2017/06/17/the-mind-bending-quest-for-cognitive-enhancers/

17/06/2017 www.pdf-archive.com

Growth factors 90%

FGFs induce the majority of their characteristic responses via binding to high-affinity cell surface receptors.

https://www.pdf-archive.com/2018/10/23/growth-factors/

23/10/2018 www.pdf-archive.com

Proto 2 90%

These chemicals enter your blood, travel to fat cells, and attach themselves at certain points known as receptors.

https://www.pdf-archive.com/2017/12/21/proto-2/

21/12/2017 www.pdf-archive.com

Thesis 2015-16 89%

The grid generation for the binding sites were used as the receptors.

https://www.pdf-archive.com/2017/07/16/thesis-2015-16/

16/07/2017 www.pdf-archive.com

biologia1 1 87%

Biologia I 3.

https://www.pdf-archive.com/2017/09/26/biologia1-1/

26/09/2017 www.pdf-archive.com

1-s2.0-S1357272505002736-main 87%

Actions are pleiotropic, mediated by membrane and nuclear receptors, other binding sites or chemical interactions.

https://www.pdf-archive.com/2014/11/25/1-s2-0-s1357272505002736-main/

25/11/2014 www.pdf-archive.com