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These patients had not responded to any standard medications, including selective serotonin re-uptake inhibitors (SSRIs) and electroconvulsive therapy.
The cognitive and biological models are each associated with empirically supported treatments, such as cognitive–behaviour therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs).
And a recent analysis reported in JAMA Psychiatry (http://www.ncbi.nlm.nih.gov/pubmed/25806940) found that the effectiveness of SSRIs in treating anxiety has been overestimated, and in some cases is no better than placebo.