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This unique, non-DNA templated mode of telomere replication requires a regulatory mechanism to ensure that telomerase acts at telomeres whose TG tracts are too short, but not at those with long tracts, thus maintaining the protective TG repeat ‘cap’ at an appropriate average length.
(4) With that trade-off as a fundamental constraint, selection adjusts telomere lengthsÐlonger telomeres increasing the capacity for repair, shorter telomeres increasing tumor resistance.
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The growth of new skin cells slows down, creating a dull, sagging complexion, and telomeres, which protect your DNA from damage, become shortened.
She unveiled that Duchenne Muscular Dystrophy (DMD)-a muscle wasting disease- is caused by deficiency of a protein called dystrophin and by shortened telomeres.
In the human genome sequence, these regions include telomeres and centromeres (chromosome tips and centers), as well as many chromosomal areas packed with other types of sequence repeats.