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There is interest in the potential risk of tumorigenesis in vivo after stem cell transplantation with several hypotheses suggesting that tumorigenesis and some side effects may be related to stem cell characteristics and modifications in stem cells during the in vitro long-term expansion.
1998 - 1999 Fogarty Senior International Fellowship, entitled “Genetic Susceptibility to Lung Tumorigenesis”, Fogarty International Center, National Institutes of Health, F06-TW02293 1999 Inaugural Research Award, Medical College of Ohio MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES:
We regard this mass of cells as a proto-tumor, each constituent cell possessing the ®rst of several mutations necessary for tumorigenesis.
doi:10.1016/j.ibmb.2010.03.002 factors modulating various physiological processes including tumorigenesis, cell cycle, neuronal differentiation, apoptosis and stress response (Takayama and Reed, 2001;