Marc Loudon, Jim Parise Organic Chemistry .pdf
Original filename: Marc Loudon, Jim Parise Organic Chemistry.pdf
Title: Organic Chemistry, SIXTH EDITION
Author: Marc Loudon and Jim Parise
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University of notre dame
W. H. Freeman and Company
One New York Plaza,
New York, NY 10004
Publisher: Ben Roberts; Production Editor: Julianna Scott Fein; Manuscript Editor: John Murdzek;
Creative Director: Emiko-Rose Paul; Text and Cover Designer: Jeanne Schreiber; Cover Art: Quade Paul;
Illustrators: Marc Loudon and Quade Paul; Photo Researcher: Sharon Donahue; Proofreader: Kate St.Clair.
The text was set in 10/12 Times LT Std by TECHarts of Colorado and printed on #40 Liberty Dull by Transcontinental Printing.
About the cover: The Aldol Condensation
The reaction on the cover is a stylized representation of the aldol condensation, one of the most important reactions in organic chemistry and a very important reaction in biology. The cover reaction is shown in the text as
Eq. 22.45 on p. 1122. Research on improvements to the aldol condensation has continued to the present time.
Discovery of the aldol condensation was announced independently in 1872 by Charles-Adolphe Wurtz, a widely
recognized French chemist, and by Alexandr Borodin, holder of a professorial chair at the Medical-Surgical
Academy in St. Petersburg. Borodin was not only a chemist and a surgeon, but was also an accomplished
amateur musician and composer whose compositions are widely played to this day. Borodin was an advocate
of women’s rights, and he also championed medical education for women. (For more on Borodin, see p. 1122.)
The cover reaction symbolizes the continuity of organic chemistry from its medical origins to the important
position it holds today as both a basic chemical discipline and a foundation of modern biology.
Copyright © 2016 by W. H. Freeman and Company, Reproduction or translation of any part of this work beyond
that permitted by Section 107 or 108 of the 1976 United States Copyright Act without permission of the copyright
owner is unlawful. Requests for permission or further information should be addressed to the Permissions
Department at W. H. Freeman and Company.
Library of Congress Cataloging-in-Publication Data
Loudon, G. Marc.
Organic chemistry / Marc Loudon, Purdue University, Jim Parise, University of Notre Dame. -- Sixth edition.
Includes bibliographical references and index.
1. Chemistry, Organic--Textbooks. I. Parise, Jim, 1978- II. Title.
Manufactured in Canada
To Tarra and Shala . . .
Wives of the sons have become daughters of the father.
and to Julian . . .
His effervescence foretells a prized vintage.
To Kat, and my family.
Chemical Bonding and Chemical Structure
Acids and Bases. The Curved-Arrow Notation
Introduction to Alkenes. Structure and Reactivity
Addition Reactions of Alkenes
Principles of Stereochemistry 229
Cyclic Compounds. Stereochemistry of Reactions 272
Noncovalent Intermolecular Interactions 324
The Chemistry of Alkyl Halides
The Chemistry of Alcohols and Thiols 452
The Chemistry of Ethers, Epoxides, Glycols, and Sulfides 511
Introduction to Spectroscopy.
Infrared Spectroscopy and Mass Spectrometry
Nuclear Magnetic Resonance Spectroscopy 611
The Chemistry of Alkynes 681
Dienes, Resonance, and Aromaticity
The Chemistry of Benzene and Its Derivatives
Allylic and Benzylic Reactivity
The Chemistry of Aryl Halides, Vinylic Halides, and Phenols.
Transition-Metal Catalysis 879
The Chemistry of Aldehydes and Ketones.
Carbonyl-Addition Reactions 946
The Chemistry of Carboxylic Acids
The Chemistry of Carboxylic Acid Derivatives 1044
The Chemistry of Enolate Ions, Enols, and
a,b-Unsaturated Carbonyl Compounds 1103
The Chemistry of Amines
The Chemistry of Thioesters, Phosphate Esters,
and Phosphate Anhydrides 1283
The Chemistry of the Aromatic Heterocycles and Nucleic
Amino Acids, Peptides, and Proteins 1373
Pericyclic Reactions 1449
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