sbmt2014 poster .pdf

File information


Original filename: sbmt2014_poster.pdf
Title: Slide 1
Author: z9100677

This PDF 1.5 document has been generated by Acrobat PDFMaker 10.1 for PowerPoint / Adobe PDF Library 10.0, and has been sent on pdf-archive.com on 13/03/2014 at 02:56, from IP address 129.94.x.x. The current document download page has been viewed 566 times.
File size: 588 KB (1 page).
Privacy: public file


Download original PDF file


sbmt2014_poster.pdf (PDF, 588 KB)


Share on social networks



Link to this file download page



Document preview


Thalamic Contributions to Remote
Memory Retrieval in Healthy
Participants and Stroke Patients
Prince of Wales Clinical School

S. Tu1,2, O. Piguet1,2, L. Miller2,3, M. Hornberger1,2
1Neuroscience

Research Australia
2ARC Centre of Excellence in Cognition and its Disorders
3Neuropsychology Unit, Royal Prince Alfred Hospital

Background: Thalamic Stroke

Long-term Memory Task

Results (Context)

 The thalamus is a major relay centre of the brain
and central for memory processes
 Focal lesions to the thalamus has been suggested
to selectively impair anterograde memory
 Damage to the mammillothalamic tract has been
suggested to be the most consistent predictor of
anterograde amnesia
 Reports in the literature are all case studies and
have never examined long-term anterograde
memory or the whole mammillothalamic tract

Recognition
‘Is this an old/new item’
Context
‘Was the item shown on the L/R’

Aims of the Study
 Assess long-term contextual memory retrieval in
thalamic stroke patients
 Assess the integrity of the mammillothalamic tract
 Identify contributions of sub-thalamic regions and
the mammillothalamic tract to anterograde
memory

 Learnt contextual location of 25 target stimuli to
criterion (> 90%, 2 consecutive training runs)
 Target stimuli intermixed with novel foils at each
assessment

Lesion Mapping

 Patients showed poorer memory retrieval
compared to controls at all delays after 24 hrs

* Thalamic lesions manually traced in each patient

Method










7 patients (mean age: 53 yrs.; education: 13 yrs.)
15 controls (mean age: 53 yrs.; education: 14 yrs.)
All patients tested > 3 years post-stroke
Administered a battery of neuropsychological tests: ACER, Doors & People, RAVLT, RCFT
Tested over 4 weeks on a novel online long-term visual
memory task for item recognition and contextual location
Structural and diffusion MRI data acquired
fMRI data acquired at baseline (recent) and 4 weeks
(remote) on the long-term memory task in a separate set
of 25 healthy controls
Imaging data analysed using FMRIB’s Software Library
(FSL)

Tractography

fMRI (Controls)
Recent Memory

Remote Memory

MRI Acquisition
 Phillips 3T MRI scanner
 Structural: 1 mm isotropic, TE/TR (2.5/5.4 ms)
 DTI: 32 directions, TR/TE/IT (8400/68/90 ms)
 fMRI: EPI sequence, TE/TR (30/3000 ms)

Functional activity
associated with correct
contextual memory
retrieval

Neuropsychological Performance
>

 Patients showed consistent lesions in the left
medio-dorsal nucleus of the thalamus
 The mammillothalamic tract (MTT) was not
damaged in patients

Greater activity
observed in the anterior
thalamus for memory
retrieval at 4 weeks

Conclusions

 Normal performance on general cognitive
screening (ACE-R)
 Impaired recall, but intact recognition

1. Thalamic stroke patients showed normal overall cognitive function, but selective deficits in immediate and longterm anterograde memory.
2. The mammillothalamic tract is a small fibre bundle that has only been reconstructed previously in a single
study with healthy young controls. This is the first study to reliably reconstruct the mammillothalamic tract in a
patient population.
3. Our results indicate that anterograde memory impairment can develop in the absence of damage to the tract
through focal lesions in the medio-dorsal nucleus (MD) of the thalamus.
4. The anterior thalamic nuclei (ATN) and MD have been suggested to subserve different memory functions. Two
of our patients had minor lesions in the right ATN, but did not differ from the remaining patients on
neuropsychological tests or long-term memory performance. This suggests that parcellation of sub-thalamic
regions to serve different memory processes may not be accurate.
5. The MD has connections to the hippocampus (HC) and prefrontal cortex (PFC). Disruption to the HC-PFC
neural pathway via the MD of the thalamus may underlie the observed impairment to long-term memory.

Contact: s.tu@neura.edu.au


Document preview sbmt2014_poster.pdf - page 1/1


Related documents


sbmt2014 poster
sfn2013 poster
neuroexamtotal
review of basic neuroscience
jdit 2014 1007 004
jdit 2015 0202 011

Link to this page


Permanent link

Use the permanent link to the download page to share your document on Facebook, Twitter, LinkedIn, or directly with a contact by e-Mail, Messenger, Whatsapp, Line..

Short link

Use the short link to share your document on Twitter or by text message (SMS)

HTML Code

Copy the following HTML code to share your document on a Website or Blog

QR Code

QR Code link to PDF file sbmt2014_poster.pdf